Hepatic, intestinal and renal transport of 1-naphthol-β- d-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia

M. H. de Vries*, F. A.M. Redegeld, A. Sj Koster, J. Noordhoek, J. G. de Haan, R. P.J. Oude Elferink, P. L.M. Jansen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Recently, a mutant rat strain was described with a genetic defect for the biliary excretion of organic anions (TR rats). To determine the possible heterogeneity of the transport systems in liver, intestine and kidney we investigated the transport of the anion 1-naphthol-β- d-glucuronide (1-NG) in isolated vascularly perfused organ preparations of the rat liver, intestine and kidney of both Wistar rats and TR rats. 1-NG was administered as such (liver and kidney experiments) or formed intracellularly from 1-naphthol (1-N) (liver and gut experiments). Independent of the type of exposure to 1-NG, the biliary excretion was considerably impaired in TR rats. In the intestine the total appearance and the vascular/luminal distribution pattern of 1-NG were not significantly different from the values in control rats. Furthermore, no significant disturbance was found with respect to the renal clearance of 1-NG in the TR rat when compared with the Wistar rat. Thus, the genetic defect in the TR rat is restricted to an impaired hepatobiliary excretion of 1-NG and does not affect the excretory systems of the intestine and kidney. These results suggest that the excretion of 1-NG by the liver, intestine and kidney involves distinct organ-specific transport systems.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume340
Issue number5
DOIs
Publication statusPublished - 1 Jan 1989

Keywords

  • 1-Naphthol-β- d-glucuronide
  • Intestine
  • Kidney
  • Liver
  • Mutant rats

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