Hematopoiesis in numbers

Jason Cosgrove, Lucie S P Hustin, Rob J de Boer, Leïla Perié

Research output: Contribution to journalReview articlepeer-review


Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~10 13 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis.

Original languageEnglish
Pages (from-to)1100-1112
Number of pages13
JournalTrends in Immunology
Issue number12
Publication statusPublished - Dec 2021


  • Animals
  • Cell Count
  • Cell Differentiation
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Mice


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