Abstract
Two ferret-adapted H5N1 viruses capable of respiratory droplet transmission have been reported with mutations in the hemagglutinin receptor-binding site and stalk domains. Glycan microarray analysis reveals that both viruses exhibit a strong shift toward binding to "human-type" α2-6 sialosides but with notable differences in fine specificity. Crystal structure analysis further shows that the stalk mutation causes no obvious perturbation of the receptor-binding pocket, consistent with its impact on hemagglutinin stability without affecting receptor specificity.
Original language | English |
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Pages (from-to) | 768-73 |
Number of pages | 6 |
Journal | Journal of Virology |
Volume | 88 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Keywords
- Hemagglutinins
- Humans
- Influenza A Virus, H5N1 Subtype