Heat-stable respiratory syncytial virus prefusion F protein oligomers and their use in immunological compositions

Cornelis A.M. de Haan; Peter Rottier; Bert Jan Haijema

Heat-stable respiratory syncytial virus prefusion F protein oligomers and their use in immunological compositions

Cornelis A.M. de Haan (Inventor), Peter Rottier (Inventor), Bert Jan Haijema (Inventor)

Mucosis BV

Research output: Patent › Other research output

Abstract

Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.

Original language	English
Patent number	PCT/EP2014/054804
IPC	C07K 14/005 (2006.01)
Priority date	14/02/13
Publication status	Published - 12 Mar 2014

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title = "Heat-stable respiratory syncytial virus prefusion F protein oligomers and their use in immunological compositions",

abstract = "Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.",

author = "{de Haan}, {Cornelis A.M.} and Peter Rottier and Haijema, {Bert Jan}",

year = "2014",

month = mar,

day = "12",

language = "English",

type = "Patent",

note = "PCT/EP2014/054804; C07K 14/005 (2006.01)",

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T1 - Heat-stable respiratory syncytial virus prefusion F protein oligomers and their use in immunological compositions

AU - de Haan, Cornelis A.M.

AU - Rottier, Peter

AU - Haijema, Bert Jan

PY - 2014/3/12

Y1 - 2014/3/12

N2 - Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.

AB - Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.

M3 - Patent

M1 - PCT/EP2014/054804

ER -

Heat-stable respiratory syncytial virus prefusion F protein oligomers and their use in immunological compositions

Abstract

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