Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Sylvia van der Pal; Stef van Buuren; Peter J. Anderson; Peter Bartmann; Nicole Baumann; Jeanie L.Y. Cheong; Brian A. Darlow; Lex W. Doyle; Kari Anne I. Evensen; John Horwood; Marit S. Indredavik; Samantha Johnson; Neil Marlow; Marina Mendonça; Yanyan Ni; Dieter Wolke; Lianne Woodward; Erik Verrips; Stavros Petrou; Corneliu  Bolbocean

doi:10.1007/s40273-022-01201-2

Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Sylvia van der Pal, Stef van Buuren, Peter J. Anderson, Peter Bartmann, Nicole Baumann, Jeanie L.Y. Cheong, Brian A. Darlow, Lex W. Doyle, Kari Anne I. Evensen, John Horwood, Marit S. Indredavik, Samantha Johnson, Neil Marlow, Marina Mendonça, Yanyan Ni, Dieter Wolke, Lianne Woodward, Erik Verrips, Stavros Petrou, Corneliu Bolbocean^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and Objective: Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods: Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results: VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions: VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.

Original language	English
Pages (from-to)	93-105
Number of pages	13
Journal	PharmacoEconomics
Volume	41
Issue number	1
DOIs	https://doi.org/10.1007/s40273-022-01201-2
Publication status	Published - 2023

Bibliographical note

Funding Information:
This work was supported by grant 733280 from the European Commission as part of the Research on European Children and Adults Born Preterm (RECAP) Consortium Preterm Project, a European Union Horizon 2020 study to construct a platform combining data from cohort studies of very preterm birth in Europe. The Victorian Infant Collaborative Study was supported by grants 491246 and 546519 from the National Health and Medical Research Council of Australia. The New Zealand Very Low Birthweight Follow up Study was supported by project grant 12-129 from the Health Research Council of New Zealand and additional funding from the Cure Kids Charitable Foundation. Participation by the Norwegian University of Science and Technology in RECAP was supported by the Research Council of Norway, project no. 283791. SP receives support as a UK National Institute for Health Research Senior Investigator (NF-SI-0616-10103) and from the UK National Institute for Health Research Applied Research Collaboration Oxford and Thames Valley.

Publisher Copyright:
© 2022, The Author(s).

Funding

This work was supported by grant 733280 from the European Commission as part of the Research on European Children and Adults Born Preterm (RECAP) Consortium Preterm Project, a European Union Horizon 2020 study to construct a platform combining data from cohort studies of very preterm birth in Europe. The Victorian Infant Collaborative Study was supported by grants 491246 and 546519 from the National Health and Medical Research Council of Australia. The New Zealand Very Low Birthweight Follow up Study was supported by project grant 12-129 from the Health Research Council of New Zealand and additional funding from the Cure Kids Charitable Foundation. Participation by the Norwegian University of Science and Technology in RECAP was supported by the Research Council of Norway, project no. 283791. SP receives support as a UK National Institute for Health Research Senior Investigator (NF-SI-0616-10103) and from the UK National Institute for Health Research Applied Research Collaboration Oxford and Thames Valley.

Funders	Funder number
Cure Kids Charitable Foundation
Norges Teknisk-Naturvitenskapelige Universitet
Horizon 2020 Framework Programme
H2020 European Research Council	733280
European Commission	546519, 491246
National Health and Medical Research Council	12-129
Health Research Council of New Zealand
Norges Forskningsråd	283791

Keywords

Adolescent
Adult
Birth Weight
Child
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Very Low Birth Weight/psychology
Prospective Studies
Quality of Life
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

van der Pal, S., van Buuren, S., Anderson, P. J., Bartmann, P., Baumann, N., Cheong, J. L. Y., Darlow, B. A., Doyle, L. W., Evensen, K. A. I., Horwood, J., Indredavik, M. S., Johnson, S., Marlow, N., Mendonça, M., Ni, Y., Wolke, D., Woodward, L., Verrips, E., Petrou, S., & Bolbocean, C. (2023). Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis. PharmacoEconomics, 41(1), 93-105. https://doi.org/10.1007/s40273-022-01201-2

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title = "Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis",

abstract = "Background and Objective: Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods: Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the {\textquoteleft}Research on European Children and Adults Born Preterm{\textquoteright} Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks{\textquoteright} gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results: VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions: VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.",

keywords = "Adolescent, Adult, Birth Weight, Child, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Very Low Birth Weight/psychology, Prospective Studies, Quality of Life, Young Adult",

author = "{van der Pal}, Sylvia and {van Buuren}, Stef and Anderson, {Peter J.} and Peter Bartmann and Nicole Baumann and Cheong, {Jeanie L.Y.} and Darlow, {Brian A.} and Doyle, {Lex W.} and Evensen, {Kari Anne I.} and John Horwood and Indredavik, {Marit S.} and Samantha Johnson and Neil Marlow and Marina Mendon{\c c}a and Yanyan Ni and Dieter Wolke and Lianne Woodward and Erik Verrips and Stavros Petrou and Corneliu Bolbocean",

note = "Funding Information: This work was supported by grant 733280 from the European Commission as part of the Research on European Children and Adults Born Preterm (RECAP) Consortium Preterm Project, a European Union Horizon 2020 study to construct a platform combining data from cohort studies of very preterm birth in Europe. The Victorian Infant Collaborative Study was supported by grants 491246 and 546519 from the National Health and Medical Research Council of Australia. The New Zealand Very Low Birthweight Follow up Study was supported by project grant 12-129 from the Health Research Council of New Zealand and additional funding from the Cure Kids Charitable Foundation. Participation by the Norwegian University of Science and Technology in RECAP was supported by the Research Council of Norway, project no. 283791. SP receives support as a UK National Institute for Health Research Senior Investigator (NF-SI-0616-10103) and from the UK National Institute for Health Research Applied Research Collaboration Oxford and Thames Valley. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

doi = "10.1007/s40273-022-01201-2",

language = "English",

volume = "41",

pages = "93--105",

journal = "PharmacoEconomics",

issn = "1170-7690",

publisher = "Adis International Ltd",

number = "1",

}

van der Pal, S, van Buuren, S, Anderson, PJ, Bartmann, P, Baumann, N, Cheong, JLY, Darlow, BA, Doyle, LW, Evensen, KAI, Horwood, J, Indredavik, MS, Johnson, S, Marlow, N, Mendonça, M, Ni, Y, Wolke, D, Woodward, L, Verrips, E, Petrou, S & Bolbocean, C 2023, 'Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis', PharmacoEconomics, vol. 41, no. 1, pp. 93-105. https://doi.org/10.1007/s40273-022-01201-2

TY - JOUR

T1 - Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults

T2 - Evidence From an Individual Participant Data Meta-Analysis

AU - van der Pal, Sylvia

AU - van Buuren, Stef

AU - Anderson, Peter J.

AU - Bartmann, Peter

AU - Baumann, Nicole

AU - Cheong, Jeanie L.Y.

AU - Darlow, Brian A.

AU - Doyle, Lex W.

AU - Evensen, Kari Anne I.

AU - Horwood, John

AU - Indredavik, Marit S.

AU - Johnson, Samantha

AU - Marlow, Neil

AU - Mendonça, Marina

AU - Ni, Yanyan

AU - Wolke, Dieter

AU - Woodward, Lianne

AU - Verrips, Erik

AU - Petrou, Stavros

AU - Bolbocean, Corneliu

N1 - Funding Information: This work was supported by grant 733280 from the European Commission as part of the Research on European Children and Adults Born Preterm (RECAP) Consortium Preterm Project, a European Union Horizon 2020 study to construct a platform combining data from cohort studies of very preterm birth in Europe. The Victorian Infant Collaborative Study was supported by grants 491246 and 546519 from the National Health and Medical Research Council of Australia. The New Zealand Very Low Birthweight Follow up Study was supported by project grant 12-129 from the Health Research Council of New Zealand and additional funding from the Cure Kids Charitable Foundation. Participation by the Norwegian University of Science and Technology in RECAP was supported by the Research Council of Norway, project no. 283791. SP receives support as a UK National Institute for Health Research Senior Investigator (NF-SI-0616-10103) and from the UK National Institute for Health Research Applied Research Collaboration Oxford and Thames Valley. Publisher Copyright: © 2022, The Author(s).

PY - 2023

Y1 - 2023

N2 - Background and Objective: Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods: Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results: VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions: VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.

AB - Background and Objective: Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods: Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results: VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions: VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.

KW - Adolescent

KW - Adult

KW - Birth Weight

KW - Child

KW - Humans

KW - Infant, Extremely Premature

KW - Infant, Newborn

KW - Infant, Very Low Birth Weight/psychology

KW - Prospective Studies

KW - Quality of Life

KW - Young Adult

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U2 - 10.1007/s40273-022-01201-2

DO - 10.1007/s40273-022-01201-2

M3 - Article

C2 - 36287335

AN - SCOPUS:85140625837

SN - 1170-7690

VL - 41

SP - 93

EP - 105

JO - PharmacoEconomics

JF - PharmacoEconomics

IS - 1

ER -

Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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