Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project

M. Bocchetta, M. Boccardi, R. Ganzola, L.G. Apostolova, G. Preboske, D. Wolf, C. Ferrari, P. Pasqualetti, N. Robitaille, S. Duchesne, C.R. Jack, G.B. Frisoni, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.

METHODS: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.

RESULTS: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).

CONCLUSION: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Original languageEnglish
Pages (from-to)151-160.e5
JournalAlzheimer's and Dementia
Volume11
Issue number2
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Atrophy
  • Cognitive Dysfunction
  • Female
  • Hippocampus
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Inservice Training
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Organ Size
  • Reproducibility of Results
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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