Abstract
BACKGROUND: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.
METHODS: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.
RESULTS: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).
CONCLUSION: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.
Original language | English |
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Pages (from-to) | 151-160.e5 |
Journal | Alzheimer's and Dementia |
Volume | 11 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 |
Externally published | Yes |
Keywords
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Atrophy
- Cognitive Dysfunction
- Female
- Hippocampus
- Humans
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Inservice Training
- Magnetic Resonance Imaging
- Male
- Neuroimaging
- Organ Size
- Reproducibility of Results
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't