Abstract
The human respiratory pathogen Haemophilus influenzae (H.i.) induced bronchial hyperreactivity to histamine (1.0-8.0 μg/100 g b.w. i.v.) in vivo in anaesthetized spontaneously breathing guinea-pigs. This hyperreactivity was caused by a potentiated increase in pulmonary resistance. Decreases in dynamic compliance did not differ. Atropine prevented the potentiation at 1.0 and 2.0 μg histamine/100 g b.w. These results show that H.i. induces bronchial hyperreactivity in vivo which is mediated by direct and reflex effects of histamine in the central airways.
| Original language | English |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 119 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 28 Mar 1985 |
Keywords
- atropine
- histamine
- airway resistance
- animal experiment
- drug antagonism
- drug efficacy
- guinea pig
- Haemophilus influenzae
- hyperreactivity
- inhalational drug administration
- intravenous drug administration
- lung resistance
- nonhuman
- potentiation
- priority journal
- respiratory system