Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates

M. Carmen Galan, Christopher S. Dodson, Andre P. Venot, Geert Jan Boons*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A range of N-acetyllactosamine derivatives, which are modified by a wide range of functionalities at C-2 and C-6, have been synthesised and the kinetic parameters of transfer catalysed by recombinant α-2,6-sialyltransferase and α-1,3-fucoyltransferase VI determined. Several of the chemical modifications led to selective modulate the activity the enzymes and offer promising lead compounds for the development of oligosaccharide primers for selective metabolic inhibition of oligosaccharide biosynthesis.

Original languageEnglish
Pages (from-to)2205-2208
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number9
DOIs
Publication statusPublished - 3 May 2004
Externally publishedYes

Keywords

  • Chemical modifications
  • Glycosyltransferase
  • Metabolic inhibition
  • Oligosaccharides

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