Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox

Tjerk J. Sminia; Han Zuilhof; Tom Wennekes

doi:10.1016/j.carres.2016.09.007

Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox

Tjerk J. Sminia, Han Zuilhof, Tom Wennekes^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.

Original language	English
Pages (from-to)	121-141
Number of pages	21
Journal	Carbohydrate Research
Volume	435
DOIs	https://doi.org/10.1016/j.carres.2016.09.007
Publication status	Published - 29 Nov 2016

Keywords

Bio-orthogonal reactions
Chemical probes
Glycans
Glycobiology
Metabolic oligosaccharide engineering

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10.1016/j.carres.2016.09.007

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abstract = "This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.",

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AB - This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.

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JO - Carbohydrate Research

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ER -

Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox

Abstract

Keywords

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