Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

Joyce Emons; Bas E. Dutilh; Eva Decker; Heide Pirzer; Carsten Sticht; Norbert Gretz; Gudrun Rappold; Ewan R. Cameron; James C. Neil; Gary S. Stein; Andre J. van Wijnen; Jan Maarten Wit; Janine N. Post; Marcel Karperien

doi:10.1530/JOE-10-0219

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

Joyce Emons, Bas E. Dutilh, Eva Decker, Heide Pirzer, Carsten Sticht, Norbert Gretz, Gudrun Rappold, Ewan R. Cameron, James C. Neil, Gary S. Stein, Andre J. van Wijnen, Jan Maarten Wit, Janine N. Post, Marcel Karperien

Sub Bioinformatics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation. In this study, we analyzed the mechanism of estrogen action using two pubertal growth plate specimens of one girl at Tanner stage B2 and Tanner stage B3. Histological analysis showed that progression of puberty coincided with characteristic morphological changes: a decrease in total growth plate height (P=0·002), height of the individual zones (P

Original language	English
Pages (from-to)	245-254
Number of pages	10
Journal	Journal of Endocrinology
Volume	209
Issue number	2
DOIs	https://doi.org/10.1530/JOE-10-0219
Publication status	Published - 1 May 2011

Keywords

cyclic AMP responsive element binding protein
estrogen receptor
STAT5b protein
transcription factor RUNX2
animal cell
article
binding site
bone growth
bone maturation
controlled study
down regulation
female
gene expression
gene mapping
genetic association
growth plate
histology
human
male
microarray analysis
mouse
nonhuman
priority journal
upregulation

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Emons, J., Dutilh, B. E., Decker, E., Pirzer, H., Sticht, C., Gretz, N., Rappold, G., Cameron, E. R., Neil, J. C., Stein, G. S., van Wijnen, A. J., Wit, J. M., Post, J. N., & Karperien, M. (2011). Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. Journal of Endocrinology, 209(2), 245-254. https://doi.org/10.1530/JOE-10-0219

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title = "Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation",

abstract = "In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation. In this study, we analyzed the mechanism of estrogen action using two pubertal growth plate specimens of one girl at Tanner stage B2 and Tanner stage B3. Histological analysis showed that progression of puberty coincided with characteristic morphological changes: a decrease in total growth plate height (P=0·002), height of the individual zones (P",

keywords = "cyclic AMP responsive element binding protein, estrogen receptor, STAT5b protein, transcription factor RUNX2, animal cell, article, binding site, bone growth, bone maturation, controlled study, down regulation, female, gene expression, gene mapping, genetic association, growth plate, histology, human, male, microarray analysis, mouse, nonhuman, priority journal, upregulation",

author = "Joyce Emons and Dutilh, {Bas E.} and Eva Decker and Heide Pirzer and Carsten Sticht and Norbert Gretz and Gudrun Rappold and Cameron, {Ewan R.} and Neil, {James C.} and Stein, {Gary S.} and {van Wijnen}, {Andre J.} and Wit, {Jan Maarten} and Post, {Janine N.} and Marcel Karperien",

year = "2011",

month = may,

day = "1",

doi = "10.1530/JOE-10-0219",

language = "English",

volume = "209",

pages = "245--254",

journal = "Journal of Endocrinology",

issn = "0022-0795",

publisher = "BioScientifica Ltd.",

number = "2",

}

Emons, J, Dutilh, BE, Decker, E, Pirzer, H, Sticht, C, Gretz, N, Rappold, G, Cameron, ER, Neil, JC, Stein, GS, van Wijnen, AJ, Wit, JM, Post, JN & Karperien, M 2011, 'Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation', Journal of Endocrinology, vol. 209, no. 2, pp. 245-254. https://doi.org/10.1530/JOE-10-0219

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T1 - Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

AU - Emons, Joyce

AU - Dutilh, Bas E.

AU - Decker, Eva

AU - Pirzer, Heide

AU - Sticht, Carsten

AU - Gretz, Norbert

AU - Rappold, Gudrun

AU - Cameron, Ewan R.

AU - Neil, James C.

AU - Stein, Gary S.

AU - van Wijnen, Andre J.

AU - Wit, Jan Maarten

AU - Post, Janine N.

AU - Karperien, Marcel

PY - 2011/5/1

Y1 - 2011/5/1

N2 - In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation. In this study, we analyzed the mechanism of estrogen action using two pubertal growth plate specimens of one girl at Tanner stage B2 and Tanner stage B3. Histological analysis showed that progression of puberty coincided with characteristic morphological changes: a decrease in total growth plate height (P=0·002), height of the individual zones (P

AB - In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation. In this study, we analyzed the mechanism of estrogen action using two pubertal growth plate specimens of one girl at Tanner stage B2 and Tanner stage B3. Histological analysis showed that progression of puberty coincided with characteristic morphological changes: a decrease in total growth plate height (P=0·002), height of the individual zones (P

KW - cyclic AMP responsive element binding protein

KW - estrogen receptor

KW - STAT5b protein

KW - transcription factor RUNX2

KW - animal cell

KW - article

KW - binding site

KW - bone growth

KW - bone maturation

KW - controlled study

KW - down regulation

KW - female

KW - gene expression

KW - gene mapping

KW - genetic association

KW - growth plate

KW - histology

KW - human

KW - male

KW - microarray analysis

KW - mouse

KW - nonhuman

KW - priority journal

KW - upregulation

U2 - 10.1530/JOE-10-0219

DO - 10.1530/JOE-10-0219

M3 - Article

C2 - 21307122

SN - 0022-0795

VL - 209

SP - 245

EP - 254

JO - Journal of Endocrinology

JF - Journal of Endocrinology

IS - 2

ER -

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

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Keywords

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