Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N Orr; E W Hill; J Gu; P Govindarajan; J Conroy; E M van Grevenhof; B J Ducro; J A M van Arendonk; J H Knaap; P R van Weeren; D E Machugh; S Ennis; P A J Brama

doi:10.1111/age.12016

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N Orr, E W Hill, J Gu, P Govindarajan, J Conroy, E M van Grevenhof, B J Ducro, J A M van Arendonk, J H Knaap, P R van Weeren, D E Machugh, S Ennis, P A J Brama

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

Original language	English
Pages (from-to)	408-412
Number of pages	5
Journal	Animal Genetics
Volume	44
Issue number	4
DOIs	https://doi.org/10.1111/age.12016
Publication status	Published - Aug 2013

Access to Document

10.1111/age.12016

Embargoed Document

275OrrAnimGen(OCassocstudy)2013
Final published version, 303 KB
Embargo ends: 1/01/50

Cite this

Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A. M., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., & Brama, P. A. J. (2013). Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. Animal Genetics, 44(4), 408-412. https://doi.org/10.1111/age.12016

@article{b5e8388f3d964a729ef4672753c2924e,

title = "Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10",

abstract = "Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).",

author = "N Orr and Hill, {E W} and J Gu and P Govindarajan and J Conroy and {van Grevenhof}, {E M} and Ducro, {B J} and {van Arendonk}, {J A M} and Knaap, {J H} and {van Weeren}, {P R} and Machugh, {D E} and S Ennis and Brama, {P A J}",

note = "{\textcopyright} 2012 The Authors, Animal Genetics {\textcopyright} 2012 Stichting International Foundation for Animal Genetics.",

year = "2013",

month = aug,

doi = "10.1111/age.12016",

language = "English",

volume = "44",

pages = "408--412",

journal = "Animal Genetics",

issn = "0268-9146",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

Orr, N, Hill, EW, Gu, J, Govindarajan, P, Conroy, J, van Grevenhof, EM, Ducro, BJ, van Arendonk, JAM, Knaap, JH, van Weeren, PR, Machugh, DE, Ennis, S & Brama, PAJ 2013, 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10', Animal Genetics, vol. 44, no. 4, pp. 408-412. https://doi.org/10.1111/age.12016

TY - JOUR

T1 - Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

AU - Orr, N

AU - Hill, E W

AU - Gu, J

AU - Govindarajan, P

AU - Conroy, J

AU - van Grevenhof, E M

AU - Ducro, B J

AU - van Arendonk, J A M

AU - Knaap, J H

AU - van Weeren, P R

AU - Machugh, D E

AU - Ennis, S

AU - Brama, P A J

PY - 2013/8

Y1 - 2013/8

N2 - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

AB - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

U2 - 10.1111/age.12016

DO - 10.1111/age.12016

M3 - Article

C2 - 23278111

SN - 0268-9146

VL - 44

SP - 408

EP - 412

JO - Animal Genetics

JF - Animal Genetics

IS - 4

ER -

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

Abstract

Access to Document

Embargoed Document

Fingerprint

Cite this