Abstract
Background:Fibromyalgia is characterised by chronic pain and a heterogene-ous presentation of other symptoms (e.g., fatigue and depression) [1]. It is widelyaccepted that pain is promoted by both genetic susceptibility and environmentalfactors such as people’s behaviours [2]. In addition to genotype individual associ-ations and gene-gene interactions, when considering complex phenotypes suchas pain, gene-environmental interactions are likely present and can help to betterunderstand the disease (i.e. by unravelling underlying mechanisms [3]).
Objectives:To test the individual association of 64 polymorphisms (34 candi-date-genes) and the gene-gene, gene-physical activity, and gene-sedentarybehaviour interactions with pain and pain-related cognitions in fibromyalgia.
Methods:In 274 women with fibromyalgia, saliva samples were collected forextracting DNA. We measured physical activity and sedentary behaviour byaccelerometers for a week, pain with algometry and questionnaires, and pain cog-nitions with questionnaires. Age, body fat, and analgesics and antidepressantsconsumption were included as covariates. Significance was set at P-values lowerthan the Bonferroni’s correction or P- and false discovery rate values lower than0.05.
Results:The rs6311 and rs6313 polymorphisms were individually related to algo-meter scores. The interaction of rs4818 and rs1799971 polymorphisms wasrelated to pain catastrophizing. Five gene-behaviour interactions were significant:the interactions of sedentary behaviour with rs1383914, rs6860, rs4680,rs165599, and rs12994338 polymorphisms were associated with the bodily painsubscale of the SF-36.
Conclusion:The HTR2A gene (individually), COMT and OPRM1 gene-geneinteraction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A,COMT, and SCN9A genes were associated with pain-related outcomes in fibro-myalgia females. Besides indicating the relevance of genetic background for painand pain-catastrophizing, the observed genotype-behaviour interactions suggestthat the effects of sedentary behaviour on pain may depend on the genotype ofwomen with fibromyalgia. Future clinical experimental research should examinewhether reducing sedentary behaviour is particularly beneficial for reducing painin women with specific genotypes
Objectives:To test the individual association of 64 polymorphisms (34 candi-date-genes) and the gene-gene, gene-physical activity, and gene-sedentarybehaviour interactions with pain and pain-related cognitions in fibromyalgia.
Methods:In 274 women with fibromyalgia, saliva samples were collected forextracting DNA. We measured physical activity and sedentary behaviour byaccelerometers for a week, pain with algometry and questionnaires, and pain cog-nitions with questionnaires. Age, body fat, and analgesics and antidepressantsconsumption were included as covariates. Significance was set at P-values lowerthan the Bonferroni’s correction or P- and false discovery rate values lower than0.05.
Results:The rs6311 and rs6313 polymorphisms were individually related to algo-meter scores. The interaction of rs4818 and rs1799971 polymorphisms wasrelated to pain catastrophizing. Five gene-behaviour interactions were significant:the interactions of sedentary behaviour with rs1383914, rs6860, rs4680,rs165599, and rs12994338 polymorphisms were associated with the bodily painsubscale of the SF-36.
Conclusion:The HTR2A gene (individually), COMT and OPRM1 gene-geneinteraction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A,COMT, and SCN9A genes were associated with pain-related outcomes in fibro-myalgia females. Besides indicating the relevance of genetic background for painand pain-catastrophizing, the observed genotype-behaviour interactions suggestthat the effects of sedentary behaviour on pain may depend on the genotype ofwomen with fibromyalgia. Future clinical experimental research should examinewhether reducing sedentary behaviour is particularly beneficial for reducing painin women with specific genotypes
| Original language | English |
|---|---|
| Article number | AB0003 |
| Pages (from-to) | 1468-1469 |
| Number of pages | 2 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 78 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2019 |
| Event | EULAR Annual European Congress of Rheumatology - Feria de Madrid, Madrid, Spain Duration: 12 Jun 2019 → 15 Jun 2019 https://www.congress.eular.org/ |