Genetically Determined Height and Risk of Non-hodgkin Lymphoma

A. Moore; E. Kane; O.A. Panagiotou; L.R. Teras; A. Monnereau; N. Wong Doo; M.J. Machiela; C.F. Skibola; S.L. Slager; G. Salles; N.J. Camp; P.M. Bracci; A. Nieters; R.C.H. Vermeulen; J. Vijai; K.E. Smedby; C.M. Vajdic; W. Cozen; J.J. Spinelli; H. Hjalgrim; G.G. Giles; B.K. Link; J. Clavel; A.A. Arslan; M.P. Purdue; L.F. Tinker; D. Albanes; G.M. Ferri; T.M. Habermann; H.-O. Adami; N. Becker; Y. Benavente; S. Bisanzi; P. Boffetta; P. Brennan; A.R. Brooks-Wilson; F. Canzian; L. Conde; D.G. Cox; K. Curtin; L. Foretova; S.M. Gapstur; H. Ghesquières; M. Glenn; B. Glimelius; R.D. Jackson; Q. Lan; M. Liebow; M. Maynadie; J. McKay; M. Melbye; L. Miligi; R.L. Milne; T.J. Molina; L.M. Morton; K.E. North; K. Offit; M. Padoan; S. Piro; V. Ravichandran; E. Riboli; S. de Sanjose; R.K. Severson; M.C. Southey; A. Staines; C. Stewart; R.C. Travis; E. Weiderpass; S. Weinstein; T. Zheng; S.J. Chanock; N. Chatterjee; N. Rothman; B.M. Birmann; J.R. Cerhan; S.I. Berndt

doi:10.3389/fonc.2019.01539

Genetically Determined Height and Risk of Non-hodgkin Lymphoma

A. Moore, E. Kane, O.A. Panagiotou, L.R. Teras, A. Monnereau, N. Wong Doo, M.J. Machiela, C.F. Skibola, S.L. Slager, G. Salles, N.J. Camp, P.M. Bracci, A. Nieters, R.C.H. Vermeulen, J. Vijai, K.E. Smedby, C.M. Vajdic, W. Cozen, J.J. Spinelli, H. HjalgrimG.G. Giles, B.K. Link, J. Clavel, A.A. Arslan, M.P. Purdue, L.F. Tinker, D. Albanes, G.M. Ferri, T.M. Habermann, H.-O. Adami, N. Becker, Y. Benavente, S. Bisanzi, P. Boffetta, P. Brennan, A.R. Brooks-Wilson, F. Canzian, L. Conde, D.G. Cox, K. Curtin, L. Foretova, S.M. Gapstur, H. Ghesquières, M. Glenn, B. Glimelius, R.D. Jackson, Q. Lan, M. Liebow, M. Maynadie, J. McKay, M. Melbye, L. Miligi, R.L. Milne, T.J. Molina, L.M. Morton, K.E. North, K. Offit, M. Padoan, S. Piro, V. Ravichandran, E. Riboli, S. de Sanjose, R.K. Severson, M.C. Southey, A. Staines, C. Stewart, R.C. Travis, E. Weiderpass, S. Weinstein, T. Zheng, S.J. Chanock, N. Chatterjee, N. Rothman, B.M. Birmann, J.R. Cerhan, S.I. Berndt

IRAS OH Epidemiology Chemical Agents

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

Original language	English
Article number	1539
Pages (from-to)	1-8
Journal	Frontiers in Oncology
Volume	9
DOIs	https://doi.org/10.3389/fonc.2019.01539
Publication status	Published - Jan 2020

Keywords

non-Hodgkin lymphoma
height
genetics
chronic lymphocytic leukemia
diffuse large B-celllymphoma
follicular lymphoma
marginal zone lymphoma
polygenic risk score

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10.3389/fonc.2019.01539Licence: CC BY

fonc-09-01539Final published version, 369 KBLicence: CC BY

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Moore, A., Kane, E., Panagiotou, O. A., Teras, L. R., Monnereau, A., Wong Doo, N., Machiela, M. J., Skibola, C. F., Slager, S. L., Salles, G., Camp, N. J., Bracci, P. M., Nieters, A., Vermeulen, R. C. H., Vijai, J., Smedby, K. E., Vajdic, C. M., Cozen, W., Spinelli, J. J., ... Berndt, S. I. (2020). Genetically Determined Height and Risk of Non-hodgkin Lymphoma. Frontiers in Oncology, 9, 1-8. Article 1539. https://doi.org/10.3389/fonc.2019.01539

@article{b746f1910a22459a80f7330896ec1ebf,

title = "Genetically Determined Height and Risk of Non-hodgkin Lymphoma",

abstract = "Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.",

keywords = "non-Hodgkin lymphoma, height, genetics, chronic lymphocytic leukemia, diffuse large B-celllymphoma, follicular lymphoma, marginal zone lymphoma, polygenic risk score",

author = "A. Moore and E. Kane and O.A. Panagiotou and L.R. Teras and A. Monnereau and {Wong Doo}, N. and M.J. Machiela and C.F. Skibola and S.L. Slager and G. Salles and N.J. Camp and P.M. Bracci and A. Nieters and R.C.H. Vermeulen and J. Vijai and K.E. Smedby and C.M. Vajdic and W. Cozen and J.J. Spinelli and H. Hjalgrim and G.G. Giles and B.K. Link and J. Clavel and A.A. Arslan and M.P. Purdue and L.F. Tinker and D. Albanes and G.M. Ferri and T.M. Habermann and H.-O. Adami and N. Becker and Y. Benavente and S. Bisanzi and P. Boffetta and P. Brennan and A.R. Brooks-Wilson and F. Canzian and L. Conde and D.G. Cox and K. Curtin and L. Foretova and S.M. Gapstur and H. Ghesqui{\`e}res and M. Glenn and B. Glimelius and R.D. Jackson and Q. Lan and M. Liebow and M. Maynadie and J. McKay and M. Melbye and L. Miligi and R.L. Milne and T.J. Molina and L.M. Morton and K.E. North and K. Offit and M. Padoan and S. Piro and V. Ravichandran and E. Riboli and {de Sanjose}, S. and R.K. Severson and M.C. Southey and A. Staines and C. Stewart and R.C. Travis and E. Weiderpass and S. Weinstein and T. Zheng and S.J. Chanock and N. Chatterjee and N. Rothman and B.M. Birmann and J.R. Cerhan and S.I. Berndt",

note = "Cited By :1 Export Date: 8 December 2021",

year = "2020",

month = jan,

doi = "10.3389/fonc.2019.01539",

language = "English",

volume = "9",

pages = "1--8",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media SA",

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Moore, A, Kane, E, Panagiotou, OA, Teras, LR, Monnereau, A, Wong Doo, N, Machiela, MJ, Skibola, CF, Slager, SL, Salles, G, Camp, NJ, Bracci, PM, Nieters, A, Vermeulen, RCH, Vijai, J, Smedby, KE, Vajdic, CM, Cozen, W, Spinelli, JJ, Hjalgrim, H, Giles, GG, Link, BK, Clavel, J, Arslan, AA, Purdue, MP, Tinker, LF, Albanes, D, Ferri, GM, Habermann, TM, Adami, H-O, Becker, N, Benavente, Y, Bisanzi, S, Boffetta, P, Brennan, P, Brooks-Wilson, AR, Canzian, F, Conde, L, Cox, DG, Curtin, K, Foretova, L, Gapstur, SM, Ghesquières, H, Glenn, M, Glimelius, B, Jackson, RD, Lan, Q, Liebow, M, Maynadie, M, McKay, J, Melbye, M, Miligi, L, Milne, RL, Molina, TJ, Morton, LM, North, KE, Offit, K, Padoan, M, Piro, S, Ravichandran, V, Riboli, E, de Sanjose, S, Severson, RK, Southey, MC, Staines, A, Stewart, C, Travis, RC, Weiderpass, E, Weinstein, S, Zheng, T, Chanock, SJ, Chatterjee, N, Rothman, N, Birmann, BM, Cerhan, JR & Berndt, SI 2020, 'Genetically Determined Height and Risk of Non-hodgkin Lymphoma', Frontiers in Oncology, vol. 9, 1539, pp. 1-8. https://doi.org/10.3389/fonc.2019.01539

TY - JOUR

T1 - Genetically Determined Height and Risk of Non-hodgkin Lymphoma

AU - Moore, A.

AU - Kane, E.

AU - Panagiotou, O.A.

AU - Teras, L.R.

AU - Monnereau, A.

AU - Wong Doo, N.

AU - Machiela, M.J.

AU - Skibola, C.F.

AU - Slager, S.L.

AU - Salles, G.

AU - Camp, N.J.

AU - Bracci, P.M.

AU - Nieters, A.

AU - Vermeulen, R.C.H.

AU - Vijai, J.

AU - Smedby, K.E.

AU - Vajdic, C.M.

AU - Cozen, W.

AU - Spinelli, J.J.

AU - Hjalgrim, H.

AU - Giles, G.G.

AU - Link, B.K.

AU - Clavel, J.

AU - Arslan, A.A.

AU - Purdue, M.P.

AU - Tinker, L.F.

AU - Albanes, D.

AU - Ferri, G.M.

AU - Habermann, T.M.

AU - Adami, H.-O.

AU - Becker, N.

AU - Benavente, Y.

AU - Bisanzi, S.

AU - Boffetta, P.

AU - Brennan, P.

AU - Brooks-Wilson, A.R.

AU - Canzian, F.

AU - Conde, L.

AU - Cox, D.G.

AU - Curtin, K.

AU - Foretova, L.

AU - Gapstur, S.M.

AU - Ghesquières, H.

AU - Glenn, M.

AU - Glimelius, B.

AU - Jackson, R.D.

AU - Lan, Q.

AU - Liebow, M.

AU - Maynadie, M.

AU - McKay, J.

AU - Melbye, M.

AU - Miligi, L.

AU - Milne, R.L.

AU - Molina, T.J.

AU - Morton, L.M.

AU - North, K.E.

AU - Offit, K.

AU - Padoan, M.

AU - Piro, S.

AU - Ravichandran, V.

AU - Riboli, E.

AU - de Sanjose, S.

AU - Severson, R.K.

AU - Southey, M.C.

AU - Staines, A.

AU - Stewart, C.

AU - Travis, R.C.

AU - Weiderpass, E.

AU - Weinstein, S.

AU - Zheng, T.

AU - Chanock, S.J.

AU - Chatterjee, N.

AU - Rothman, N.

AU - Birmann, B.M.

AU - Cerhan, J.R.

AU - Berndt, S.I.

N1 - Cited By :1 Export Date: 8 December 2021

PY - 2020/1

Y1 - 2020/1

N2 - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

AB - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

KW - non-Hodgkin lymphoma

KW - height

KW - genetics

KW - chronic lymphocytic leukemia

KW - diffuse large B-celllymphoma

KW - follicular lymphoma

KW - marginal zone lymphoma

KW - polygenic risk score

UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079502127&doi=10.3389%2ffonc.2019.01539&partnerID=40&md5=7623ec625ce73bef6e7b89d062debd40

U2 - 10.3389/fonc.2019.01539

DO - 10.3389/fonc.2019.01539

M3 - Article

SN - 2234-943X

VL - 9

SP - 1

EP - 8

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1539

ER -

Genetically Determined Height and Risk of Non-hodgkin Lymphoma

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