Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Mitchell J Machiela; Chao Agnes Hsiung; Xiao-Ou Shu; Wei Jie Seow; Zhaoming Wang; Keitaro Matsuo; Yun-Chul Hong; Adeline Seow; Chen Wu; H Dean Hosgood; Kexin Chen; Jiu-Cun Wang; Wanqing Wen; Richard Cawthon; Nilanjan Chatterjee; Wei Hu; Neil E Caporaso; Jae Yong Park; Chien-Jen Chen; Yeul Hong Kim; Young Tae Kim; Maria Teresa Landi; Hongbing Shen; Charles Lawrence; Laurie Burdett; Meredith Yeager; I-Shou Chang; Tetsuya Mitsudomi; Hee Nam Kim; Gee-Chen Chang; Bryan A Bassig; Margaret Tucker; Fusheng Wei; Zhihua Yin; She-Juan An; Biyun Qian; Victor Ho Fun Lee; Daru Lu; Jianjun Liu; Hyo-Sung Jeon; Chin-Fu Hsiao; Jae Sook Sung; Jin Hee Kim; Yu-Tang Gao; Ying-Huang Tsai; Yoo Jin Jung; Huan Guo; Zhibin Hu; Amy Hutchinson; Wen-Chang Wang; Robert J Klein; Charles C Chung; In-Jae Oh; Kuan-Yu Chen; Sonja I Berndt; Wei Wu; Jiang Chang; Xu-Chao Zhang; Ming-Shyan Huang; Hong Zheng; Junwen Wang; Xueying Zhao; Yuqing Li; Jin Eun Choi; Wu-Chou Su; Kyong Hwa Park; Sook Whan Sung; Yuh-Min Chen; Li Liu; Chang Hyun Kang; Lingmin Hu; Chung-Hsing Chen; William Pao; Young-Chul Kim; Tsung-Ying Yang; Jun Xu; Peng Guan; Wen Tan; Jian Su; Chih-Liang Wang; Haixin Li; Alan Dart Loon Sihoe; Zhenhong Zhao; Ying Chen; Yi Young Choi; Jen-Yu Hung; Jun Suk Kim; Ho-Il Yoon; Qiuyin Cai; Chien-Chung Lin; In Kyu Park; Ping Xu; Jing Dong; Christopher Kim; Qincheng He; Reury-Perng Perng; Takashi Kohno; Sun-Seog Kweon; Chih-Yi Chen; Roel C H Vermeulen; Junjie Wu; Wei-Yen Lim; Kun-Chieh Chen; Wong-Ho Chow; Bu-Tian Ji; John K C Chan; Minjie Chu; Yao-Jen Li; Jun Yokota; Jihua Li; Hongyan Chen; Yong-Bing Xiang; Chong-Jen Yu; Hideo Kunitoh; Guoping Wu; Li Jin; Yen-Li Lo; Kouya Shiraishi; Ying-Hsiang Chen; Hsien-Chih Lin; Tangchun Wu; Maria Pik Wong; Yi-Long Wu; Pan-Chyr Yang; Baosen Zhou; Min-Ho Shin; Joseph F Fraumeni; Wei Zheng; Dongxin Lin; Stephen J Chanock; Nathaniel Rothman; Qing Lan

doi:10.1002/ijc.29393

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Mitchell J Machiela, Chao Agnes Hsiung, Xiao-Ou Shu, Wei Jie Seow, Zhaoming Wang, Keitaro Matsuo, Yun-Chul Hong, Adeline Seow, Chen Wu, H Dean Hosgood, Kexin Chen, Jiu-Cun Wang, Wanqing Wen, Richard Cawthon, Nilanjan Chatterjee, Wei Hu, Neil E Caporaso, Jae Yong Park, Chien-Jen Chen, Yeul Hong KimYoung Tae Kim, Maria Teresa Landi, Hongbing Shen, Charles Lawrence, Laurie Burdett, Meredith Yeager, I-Shou Chang, Tetsuya Mitsudomi, Hee Nam Kim, Gee-Chen Chang, Bryan A Bassig, Margaret Tucker, Fusheng Wei, Zhihua Yin, She-Juan An, Biyun Qian, Victor Ho Fun Lee, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Jin Hee Kim, Yu-Tang Gao, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Amy Hutchinson, Wen-Chang Wang, Robert J Klein, Charles C Chung, In-Jae Oh, Kuan-Yu Chen, Sonja I Berndt, Wei Wu, Jiang Chang, Xu-Chao Zhang, Ming-Shyan Huang, Hong Zheng, Junwen Wang, Xueying Zhao, Yuqing Li, Jin Eun Choi, Wu-Chou Su, Kyong Hwa Park, Sook Whan Sung, Yuh-Min Chen, Li Liu, Chang Hyun Kang, Lingmin Hu, Chung-Hsing Chen, William Pao, Young-Chul Kim, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Jian Su, Chih-Liang Wang, Haixin Li, Alan Dart Loon Sihoe, Zhenhong Zhao, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, Chien-Chung Lin, In Kyu Park, Ping Xu, Jing Dong, Christopher Kim, Qincheng He, Reury-Perng Perng, Takashi Kohno, Sun-Seog Kweon, Chih-Yi Chen, Roel C H Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, Wong-Ho Chow, Bu-Tian Ji, John K C Chan, Minjie Chu, Yao-Jen Li, Jun Yokota, Jihua Li, Hongyan Chen, Yong-Bing Xiang, Chong-Jen Yu, Hideo Kunitoh, Guoping Wu, Li Jin, Yen-Li Lo, Kouya Shiraishi, Ying-Hsiang Chen, Hsien-Chih Lin, Tangchun Wu, Maria Pik Wong, Yi-Long Wu, Pan-Chyr Yang, Baosen Zhou, Min-Ho Shin, Joseph F Fraumeni, Wei Zheng, Dongxin Lin, Stephen J Chanock, Nathaniel Rothman, Qing Lan

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.

Original language	English
Pages (from-to)	311-9
Number of pages	9
Journal	International Journal of Cancer
Volume	137
Issue number	2
DOIs	https://doi.org/10.1002/ijc.29393
Publication status	Published - 15 Jul 2015

Keywords

Adult
Aged
Asian Continental Ancestry Group
China
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Hong Kong
Humans
Japan
Lung Neoplasms
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Prospective Studies
Republic of Korea
Risk Factors
Singapore
Smoking
Taiwan
Telomere
Telomere Homeostasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.29393

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Machiela, M. J., Hsiung, C. A., Shu, X.-O., Seow, W. J., Wang, Z., Matsuo, K., Hong, Y.-C., Seow, A., Wu, C., Hosgood, H. D., Chen, K., Wang, J.-C., Wen, W., Cawthon, R., Chatterjee, N., Hu, W., Caporaso, N. E., Park, J. Y., Chen, C.-J., ... Lan, Q. (2015). Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. International Journal of Cancer, 137(2), 311-9. https://doi.org/10.1002/ijc.29393

@article{7be0715384fd48949b191f2a17209167,

title = "Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia",

abstract = "Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.",

keywords = "Adult, Aged, Asian Continental Ancestry Group, China, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Hong Kong, Humans, Japan, Lung Neoplasms, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Prospective Studies, Republic of Korea, Risk Factors, Singapore, Smoking, Taiwan, Telomere, Telomere Homeostasis",

author = "Machiela, {Mitchell J} and Hsiung, {Chao Agnes} and Xiao-Ou Shu and Seow, {Wei Jie} and Zhaoming Wang and Keitaro Matsuo and Yun-Chul Hong and Adeline Seow and Chen Wu and Hosgood, {H Dean} and Kexin Chen and Jiu-Cun Wang and Wanqing Wen and Richard Cawthon and Nilanjan Chatterjee and Wei Hu and Caporaso, {Neil E} and Park, {Jae Yong} and Chien-Jen Chen and Kim, {Yeul Hong} and Kim, {Young Tae} and Landi, {Maria Teresa} and Hongbing Shen and Charles Lawrence and Laurie Burdett and Meredith Yeager and I-Shou Chang and Tetsuya Mitsudomi and Kim, {Hee Nam} and Gee-Chen Chang and Bassig, {Bryan A} and Margaret Tucker and Fusheng Wei and Zhihua Yin and She-Juan An and Biyun Qian and Lee, {Victor Ho Fun} and Daru Lu and Jianjun Liu and Hyo-Sung Jeon and Chin-Fu Hsiao and Sung, {Jae Sook} and Kim, {Jin Hee} and Yu-Tang Gao and Ying-Huang Tsai and Jung, {Yoo Jin} and Huan Guo and Zhibin Hu and Amy Hutchinson and Wen-Chang Wang and Klein, {Robert J} and Chung, {Charles C} and In-Jae Oh and Kuan-Yu Chen and Berndt, {Sonja I} and Wei Wu and Jiang Chang and Xu-Chao Zhang and Ming-Shyan Huang and Hong Zheng and Junwen Wang and Xueying Zhao and Yuqing Li and Choi, {Jin Eun} and Wu-Chou Su and Park, {Kyong Hwa} and Sung, {Sook Whan} and Yuh-Min Chen and Li Liu and Kang, {Chang Hyun} and Lingmin Hu and Chung-Hsing Chen and William Pao and Young-Chul Kim and Tsung-Ying Yang and Jun Xu and Peng Guan and Wen Tan and Jian Su and Chih-Liang Wang and Haixin Li and Sihoe, {Alan Dart Loon} and Zhenhong Zhao and Ying Chen and Choi, {Yi Young} and Jen-Yu Hung and Kim, {Jun Suk} and Ho-Il Yoon and Qiuyin Cai and Chien-Chung Lin and Park, {In Kyu} and Ping Xu and Jing Dong and Christopher Kim and Qincheng He and Reury-Perng Perng and Takashi Kohno and Sun-Seog Kweon and Chih-Yi Chen and Vermeulen, {Roel C H} and Junjie Wu and Wei-Yen Lim and Kun-Chieh Chen and Wong-Ho Chow and Bu-Tian Ji and Chan, {John K C} and Minjie Chu and Yao-Jen Li and Jun Yokota and Jihua Li and Hongyan Chen and Yong-Bing Xiang and Chong-Jen Yu and Hideo Kunitoh and Guoping Wu and Li Jin and Yen-Li Lo and Kouya Shiraishi and Ying-Hsiang Chen and Hsien-Chih Lin and Tangchun Wu and Wong, {Maria Pik} and Yi-Long Wu and Pan-Chyr Yang and Baosen Zhou and Min-Ho Shin and Fraumeni, {Joseph F} and Wei Zheng and Dongxin Lin and Chanock, {Stephen J} and Nathaniel Rothman and Qing Lan",

year = "2015",

month = jul,

day = "15",

doi = "10.1002/ijc.29393",

language = "English",

volume = "137",

pages = "311--9",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Machiela, MJ, Hsiung, CA, Shu, X-O, Seow, WJ, Wang, Z, Matsuo, K, Hong, Y-C, Seow, A, Wu, C, Hosgood, HD, Chen, K, Wang, J-C, Wen, W, Cawthon, R, Chatterjee, N, Hu, W, Caporaso, NE, Park, JY, Chen, C-J, Kim, YH, Kim, YT, Landi, MT, Shen, H, Lawrence, C, Burdett, L, Yeager, M, Chang, I-S, Mitsudomi, T, Kim, HN, Chang, G-C, Bassig, BA, Tucker, M, Wei, F, Yin, Z, An, S-J, Qian, B, Lee, VHF, Lu, D, Liu, J, Jeon, H-S, Hsiao, C-F, Sung, JS, Kim, JH, Gao, Y-T, Tsai, Y-H, Jung, YJ, Guo, H, Hu, Z, Hutchinson, A, Wang, W-C, Klein, RJ, Chung, CC, Oh, I-J, Chen, K-Y, Berndt, SI, Wu, W, Chang, J, Zhang, X-C, Huang, M-S, Zheng, H, Wang, J, Zhao, X, Li, Y, Choi, JE, Su, W-C, Park, KH, Sung, SW, Chen, Y-M, Liu, L, Kang, CH, Hu, L, Chen, C-H, Pao, W, Kim, Y-C, Yang, T-Y, Xu, J, Guan, P, Tan, W, Su, J, Wang, C-L, Li, H, Sihoe, ADL, Zhao, Z, Chen, Y, Choi, YY, Hung, J-Y, Kim, JS, Yoon, H-I, Cai, Q, Lin, C-C, Park, IK, Xu, P, Dong, J, Kim, C, He, Q, Perng, R-P, Kohno, T, Kweon, S-S, Chen, C-Y, Vermeulen, RCH, Wu, J, Lim, W-Y, Chen, K-C, Chow, W-H, Ji, B-T, Chan, JKC, Chu, M, Li, Y-J, Yokota, J, Li, J, Chen, H, Xiang, Y-B, Yu, C-J, Kunitoh, H, Wu, G, Jin, L, Lo, Y-L, Shiraishi, K, Chen, Y-H, Lin, H-C, Wu, T, Wong, MP, Wu, Y-L, Yang, P-C, Zhou, B, Shin, M-H, Fraumeni, JF, Zheng, W, Lin, D, Chanock, SJ, Rothman, N & Lan, Q 2015, 'Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia', International Journal of Cancer, vol. 137, no. 2, pp. 311-9. https://doi.org/10.1002/ijc.29393

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. / Machiela, Mitchell J; Hsiung, Chao Agnes; Shu, Xiao-Ou et al.
In: International Journal of Cancer, Vol. 137, No. 2, 15.07.2015, p. 311-9.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia

T2 - a report from the female lung cancer consortium in Asia

AU - Machiela, Mitchell J

AU - Hsiung, Chao Agnes

AU - Shu, Xiao-Ou

AU - Seow, Wei Jie

AU - Wang, Zhaoming

AU - Matsuo, Keitaro

AU - Hong, Yun-Chul

AU - Seow, Adeline

AU - Wu, Chen

AU - Hosgood, H Dean

AU - Chen, Kexin

AU - Wang, Jiu-Cun

AU - Wen, Wanqing

AU - Cawthon, Richard

AU - Chatterjee, Nilanjan

AU - Hu, Wei

AU - Caporaso, Neil E

AU - Park, Jae Yong

AU - Chen, Chien-Jen

AU - Kim, Yeul Hong

AU - Kim, Young Tae

AU - Landi, Maria Teresa

AU - Shen, Hongbing

AU - Lawrence, Charles

AU - Burdett, Laurie

AU - Yeager, Meredith

AU - Chang, I-Shou

AU - Mitsudomi, Tetsuya

AU - Kim, Hee Nam

AU - Chang, Gee-Chen

AU - Bassig, Bryan A

AU - Tucker, Margaret

AU - Wei, Fusheng

AU - Yin, Zhihua

AU - An, She-Juan

AU - Qian, Biyun

AU - Lee, Victor Ho Fun

AU - Lu, Daru

AU - Liu, Jianjun

AU - Jeon, Hyo-Sung

AU - Hsiao, Chin-Fu

AU - Sung, Jae Sook

AU - Kim, Jin Hee

AU - Gao, Yu-Tang

AU - Tsai, Ying-Huang

AU - Jung, Yoo Jin

AU - Guo, Huan

AU - Hu, Zhibin

AU - Hutchinson, Amy

AU - Wang, Wen-Chang

AU - Klein, Robert J

AU - Chung, Charles C

AU - Oh, In-Jae

AU - Chen, Kuan-Yu

AU - Berndt, Sonja I

AU - Wu, Wei

AU - Chang, Jiang

AU - Zhang, Xu-Chao

AU - Huang, Ming-Shyan

AU - Zheng, Hong

AU - Wang, Junwen

AU - Zhao, Xueying

AU - Li, Yuqing

AU - Choi, Jin Eun

AU - Su, Wu-Chou

AU - Park, Kyong Hwa

AU - Sung, Sook Whan

AU - Chen, Yuh-Min

AU - Liu, Li

AU - Kang, Chang Hyun

AU - Hu, Lingmin

AU - Chen, Chung-Hsing

AU - Pao, William

AU - Kim, Young-Chul

AU - Yang, Tsung-Ying

AU - Xu, Jun

AU - Guan, Peng

AU - Tan, Wen

AU - Su, Jian

AU - Wang, Chih-Liang

AU - Li, Haixin

AU - Sihoe, Alan Dart Loon

AU - Zhao, Zhenhong

AU - Chen, Ying

AU - Choi, Yi Young

AU - Hung, Jen-Yu

AU - Kim, Jun Suk

AU - Yoon, Ho-Il

AU - Cai, Qiuyin

AU - Lin, Chien-Chung

AU - Park, In Kyu

AU - Xu, Ping

AU - Dong, Jing

AU - Kim, Christopher

AU - He, Qincheng

AU - Perng, Reury-Perng

AU - Kohno, Takashi

AU - Kweon, Sun-Seog

AU - Chen, Chih-Yi

AU - Vermeulen, Roel C H

AU - Wu, Junjie

AU - Lim, Wei-Yen

AU - Chen, Kun-Chieh

AU - Chow, Wong-Ho

AU - Ji, Bu-Tian

AU - Chan, John K C

AU - Chu, Minjie

AU - Li, Yao-Jen

AU - Yokota, Jun

AU - Li, Jihua

AU - Chen, Hongyan

AU - Xiang, Yong-Bing

AU - Yu, Chong-Jen

AU - Kunitoh, Hideo

AU - Wu, Guoping

AU - Jin, Li

AU - Lo, Yen-Li

AU - Shiraishi, Kouya

AU - Chen, Ying-Hsiang

AU - Lin, Hsien-Chih

AU - Wu, Tangchun

AU - Wong, Maria Pik

AU - Wu, Yi-Long

AU - Yang, Pan-Chyr

AU - Zhou, Baosen

AU - Shin, Min-Ho

AU - Fraumeni, Joseph F

AU - Zheng, Wei

AU - Lin, Dongxin

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Lan, Qing

PY - 2015/7/15

Y1 - 2015/7/15

N2 - Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.

AB - Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.

KW - Adult

KW - Aged

KW - Asian Continental Ancestry Group

KW - China

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Hong Kong

KW - Humans

KW - Japan

KW - Lung Neoplasms

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Republic of Korea

KW - Risk Factors

KW - Singapore

KW - Smoking

KW - Taiwan

KW - Telomere

KW - Telomere Homeostasis

U2 - 10.1002/ijc.29393

DO - 10.1002/ijc.29393

M3 - Article

C2 - 25516442

SN - 0020-7136

VL - 137

SP - 311

EP - 319

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Abstract

Keywords

UN SDGs

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