Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children

Rabia R. Chhangur; Joyce Weeland; Geertjan Overbeek; Walter Matthys; Bram Orobio De Castro; Danielle Van Der Giessen; Jay Belsky

doi:10.1111/cdev.12612

Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children

Rabia R. Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio De Castro, Danielle Van Der Giessen, Jay Belsky

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents’ manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).

Original language	English
Pages (from-to)	796-811
Journal	Child Development
Volume	88
Issue number	3
DOIs	https://doi.org/10.1111/cdev.12612
Publication status	Published - May 2017

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title = "Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children",

abstract = "This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents{\textquoteright} manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).",

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AU - Weeland, Joyce

AU - Overbeek, Geertjan

AU - Matthys, Walter

AU - Orobio De Castro, Bram

AU - Van Der Giessen, Danielle

AU - Belsky, Jay

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Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children

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