Genetic engineering for strain improvement in filamentous fungi

Sandra Garrigues; Natalia Martinez-Reyes; Ronald P. de Vries

doi:10.1016/B978-0-12-819990-9.00006-8

Genetic engineering for strain improvement in filamentous fungi

Sandra Garrigues, Natalia Martinez-Reyes, Ronald P. de Vries

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Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Strain improvement is highly important for the development of biotechnology processes in which filamentous fungi are applied, since native strains often do not have the production or performance levels needed. Genetic engineering is a highly powerful tool to obtain the required improvements, but the different approaches for this each have advantages and disadvantages. In this article, the different genetic engineering methods (both GMO and non-GMO) are summarized and examples of their applications are given.

Original language	English
Title of host publication	Reference Module in Life Sciences 2020
Editors	Ronald de Vries, Miia MÃ¤kelÃ¤
Publisher	Elsevier
DOIs	https://doi.org/10.1016/B978-0-12-819990-9.00006-8
Publication status	Published - 2020

Keywords

Adaptive evolution
CRISPR/Cas9
Gene overexpression
Genetic engineering
Mutagenesis
Mutations
Regulation
RNA interference
TALEN
Transformation
ZNF

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10.1016/B978-0-12-819990-9.00006-8

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title = "Genetic engineering for strain improvement in filamentous fungi",

abstract = "Strain improvement is highly important for the development of biotechnology processes in which filamentous fungi are applied, since native strains often do not have the production or performance levels needed. Genetic engineering is a highly powerful tool to obtain the required improvements, but the different approaches for this each have advantages and disadvantages. In this article, the different genetic engineering methods (both GMO and non-GMO) are summarized and examples of their applications are given.",

keywords = "Adaptive evolution, CRISPR/Cas9, Gene overexpression, Genetic engineering, Mutagenesis, Mutations, Regulation, RNA interference, TALEN, Transformation, ZNF",

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T1 - Genetic engineering for strain improvement in filamentous fungi

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AU - Martinez-Reyes, Natalia

AU - de Vries, Ronald P.

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AB - Strain improvement is highly important for the development of biotechnology processes in which filamentous fungi are applied, since native strains often do not have the production or performance levels needed. Genetic engineering is a highly powerful tool to obtain the required improvements, but the different approaches for this each have advantages and disadvantages. In this article, the different genetic engineering methods (both GMO and non-GMO) are summarized and examples of their applications are given.

KW - Adaptive evolution

KW - CRISPR/Cas9

KW - Gene overexpression

KW - Genetic engineering

KW - Mutagenesis

KW - Mutations

KW - Regulation

KW - RNA interference

KW - TALEN

KW - Transformation

KW - ZNF

U2 - 10.1016/B978-0-12-819990-9.00006-8

DO - 10.1016/B978-0-12-819990-9.00006-8

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BT - Reference Module in Life Sciences 2020

A2 - de Vries, Ronald

A2 - MÃ¤kelÃ¤, Miia

PB - Elsevier

ER -

Genetic engineering for strain improvement in filamentous fungi

Abstract

Keywords

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