Genetic determinants of response to statins

Bas J M Peters; Olaf H Klungel; Anthonius de Boer; Anke-Hilse Maitland-van der Zee

doi:10.1586/erc.09.83

Genetic determinants of response to statins

Bas J M Peters, Olaf H Klungel, Anthonius de Boer, Anke-Hilse Maitland-van der Zee

Dept of Pharmaceutical Sciences

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy.

Original language	English
Pages (from-to)	977-983
Number of pages	7
Journal	Expert Review of Cardiovascular Therapy
Volume	7
Issue number	8
DOIs	https://doi.org/10.1586/erc.09.83
Publication status	Published - Aug 2009

Keywords

Anticholesteremic Agents
Cardiovascular Diseases
Coronary Artery Disease
Genetic Variation
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Pharmacogenetics
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/erc.09.83

Cite this

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title = "Genetic determinants of response to statins",

abstract = "In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy.",

keywords = "Anticholesteremic Agents, Cardiovascular Diseases, Coronary Artery Disease, Genetic Variation, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Pharmacogenetics, Risk Factors",

author = "Peters, {Bas J M} and Klungel, {Olaf H} and {de Boer}, Anthonius and {Maitland-van der Zee}, Anke-Hilse",

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AU - Klungel, Olaf H

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AB - In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy.

KW - Anticholesteremic Agents

KW - Cardiovascular Diseases

KW - Coronary Artery Disease

KW - Genetic Variation

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Hypercholesterolemia

KW - Pharmacogenetics

KW - Risk Factors

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JO - Expert Review of Cardiovascular Therapy

JF - Expert Review of Cardiovascular Therapy

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ER -

Genetic determinants of response to statins

Abstract

Keywords

UN SDGs

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