Gender-specific alterations of cerebral metabolites with aging and cortisol treatment

T Michaelis; G de Biurrun; T Watanabe; J Frahm; F Ohl; E Fuchs; Frauke Ohl

Gender-specific alterations of cerebral metabolites with aging and cortisol treatment

T Michaelis^*, G de Biurrun, T Watanabe, J Frahm, F Ohl, E Fuchs, Frauke Ohl

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Excess availability of the adrenocortical glucocorticoid hormone cortisol has been correlated with structural brain changes and a decline of cognitive functions during aging. Pertinent studies need to consider gender as a potential confound because of sexual dimorphism in the regulation of hypothalamus-pituitary-adrenal axis activity. In vivo localized proton magnetic resonance spectroscopy of male and female tree shrews revealed similar concentrations of cerebral metabolites in young adult animals but gender-specific alterations with aging as well as in response to cortisol, treatment. In comparison with adult tree shrews, aged males had reduced concentrations of N-acetylaspartate (-33%; P

Original language	English
Pages (from-to)	231-237
Number of pages	7
Journal	Journal of Psychiatric Research
Volume	35
Issue number	4
Publication status	Published - 2001

Keywords

brain
metabolism
aging
gender
cortisol
magnetic resonance spectroscopy
MAGNETIC-RESONANCE SPECTROSCOPY
CENTRAL-NERVOUS-SYSTEM
HUMAN BRAIN
TREE SHREWS
TUPAIA-BELANGERI
PROTON MRS
PSYCHOSOCIAL STRESS
ENDOCRINE CHANGES
RECEPTOR
CREATINE

Cite this

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title = "Gender-specific alterations of cerebral metabolites with aging and cortisol treatment",

abstract = "Excess availability of the adrenocortical glucocorticoid hormone cortisol has been correlated with structural brain changes and a decline of cognitive functions during aging. Pertinent studies need to consider gender as a potential confound because of sexual dimorphism in the regulation of hypothalamus-pituitary-adrenal axis activity. In vivo localized proton magnetic resonance spectroscopy of male and female tree shrews revealed similar concentrations of cerebral metabolites in young adult animals but gender-specific alterations with aging as well as in response to cortisol, treatment. In comparison with adult tree shrews, aged males had reduced concentrations of N-acetylaspartate (-33%; P",

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author = "T Michaelis and {de Biurrun}, G and T Watanabe and J Frahm and F Ohl and E Fuchs and Frauke Ohl",

year = "2001",

language = "English",

volume = "35",

pages = "231--237",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Gender-specific alterations of cerebral metabolites with aging and cortisol treatment

AU - Michaelis, T

AU - de Biurrun, G

AU - Watanabe, T

AU - Frahm, J

AU - Ohl, F

AU - Fuchs, E

AU - Ohl, Frauke

PY - 2001

Y1 - 2001

N2 - Excess availability of the adrenocortical glucocorticoid hormone cortisol has been correlated with structural brain changes and a decline of cognitive functions during aging. Pertinent studies need to consider gender as a potential confound because of sexual dimorphism in the regulation of hypothalamus-pituitary-adrenal axis activity. In vivo localized proton magnetic resonance spectroscopy of male and female tree shrews revealed similar concentrations of cerebral metabolites in young adult animals but gender-specific alterations with aging as well as in response to cortisol, treatment. In comparison with adult tree shrews, aged males had reduced concentrations of N-acetylaspartate (-33%; P

AB - Excess availability of the adrenocortical glucocorticoid hormone cortisol has been correlated with structural brain changes and a decline of cognitive functions during aging. Pertinent studies need to consider gender as a potential confound because of sexual dimorphism in the regulation of hypothalamus-pituitary-adrenal axis activity. In vivo localized proton magnetic resonance spectroscopy of male and female tree shrews revealed similar concentrations of cerebral metabolites in young adult animals but gender-specific alterations with aging as well as in response to cortisol, treatment. In comparison with adult tree shrews, aged males had reduced concentrations of N-acetylaspartate (-33%; P

KW - brain

KW - metabolism

KW - aging

KW - gender

KW - cortisol

KW - magnetic resonance spectroscopy

KW - MAGNETIC-RESONANCE SPECTROSCOPY

KW - CENTRAL-NERVOUS-SYSTEM

KW - HUMAN BRAIN

KW - TREE SHREWS

KW - TUPAIA-BELANGERI

KW - PROTON MRS

KW - PSYCHOSOCIAL STRESS

KW - ENDOCRINE CHANGES

KW - RECEPTOR

KW - CREATINE

M3 - Article

SN - 0022-3956

VL - 35

SP - 231

EP - 237

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 4

ER -

Gender-specific alterations of cerebral metabolites with aging and cortisol treatment

Abstract

Keywords

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