GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins

Cristina M Dorobantu; Lauren A Ford-Siltz; Simone P Sittig; Kjerstin H W Lanke; George A Belov; Frank J M van Kuppeveld; Hilde M van der Schaar

doi:10.1128/JVI.02830-14

GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins

Cristina M Dorobantu, Lauren A Ford-Siltz, Simone P Sittig, Kjerstin H W Lanke, George A Belov, Frank J M van Kuppeveld, Hilde M van der Schaar

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses like poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although previously HRV 3A was shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.

Original language	English
Journal	Journal of Virology
DOIs	https://doi.org/10.1128/JVI.02830-14
Publication status	Published - 19 Nov 2014

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title = "GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins",

abstract = "PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses like poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although previously HRV 3A was shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.",

author = "Dorobantu, {Cristina M} and Ford-Siltz, {Lauren A} and Sittig, {Simone P} and Lanke, {Kjerstin H W} and Belov, {George A} and {van Kuppeveld}, {Frank J M} and {van der Schaar}, {Hilde M}",

year = "2014",

month = nov,

day = "19",

doi = "10.1128/JVI.02830-14",

language = "English",

journal = "Journal of Virology",

issn = "0022-538X",

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T1 - GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins

AU - Dorobantu, Cristina M

AU - Ford-Siltz, Lauren A

AU - Sittig, Simone P

AU - Lanke, Kjerstin H W

AU - Belov, George A

AU - van Kuppeveld, Frank J M

AU - van der Schaar, Hilde M

PY - 2014/11/19

Y1 - 2014/11/19

N2 - PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses like poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although previously HRV 3A was shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.

AB - PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses like poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although previously HRV 3A was shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.

U2 - 10.1128/JVI.02830-14

DO - 10.1128/JVI.02830-14

M3 - Article

C2 - 25410869

SN - 0022-538X

JO - Journal of Virology

JF - Journal of Virology

ER -

GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins

Abstract

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