Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential

Sam C. Ogden; Marc T. Nishimura; Dmitry Lapin

doi:10.1016/j.pbi.2023.102481

Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential

Sam C. Ogden, Marc T. Nishimura^*, Dmitry Lapin^*

^*Corresponding author for this work

Colorado State University

Research output: Contribution to journal › Review article › peer-review

Abstract

Across the Tree of Life, innate immunity and cell death mechanisms protect hosts from potential pathogens. In prokaryotes, animals, and flowering plants, these functions are often mediated by Toll/interleukin-1 receptor (TIR) domain proteins. Here, we discuss recent analyses of TIR biology in flowering plants, revealing (i) TIR functions beyond pathogen recognition, e.g. in the spatial control of immunity, and (ii) the existence of at least two pathways for TIR signaling in plants. Also, we discuss TIR-based strategies for crop improvement and argue for a need to better understand TIR functions outside of commonly studied dicot pathways for future translational work. Opinions of experts on emerging topics in basic and translational plant TIR research are presented in supplementary video interviews.

Original language	English
Article number	102481
Number of pages	9
Journal	Current Opinion in Plant Biology
Volume	76
DOIs	https://doi.org/10.1016/j.pbi.2023.102481
Publication status	Published - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Funding

This work was supported by funding from the NSF (IOS-1758400) and Syngenta Crop Protection, LLC to MTN. SO was supported by a USDA-NIFA predoctoral fellowship (012095-00002). DL was supported by Utrecht University and LettuceKnow project, project number 2.1 of the research Perspective Program P19-17 which is (partly) financed by the Dutch Research Council (NWO) and the breeding companies BASF, Bejo Zaden B.V. Limagrain, Enza Zaden Research & Development B.V. Rijk Zwaan Breeding B.V. Syngenta Seeds B.V. and Takii and Company Ltd. Figures were prepared with BioRender.com. We thank Jane E. Parker (Max Planck Institute for Plant Breeding Research, Germany) and Johnathan D. Jones (The Sainsbury Laboratory, the United Kingdom) for their expert opinions shown in the supplementary videos in this paper. This work was supported by funding from the NSF ( IOS-1758400 ) and Syngenta Crop Protection, LLC to MTN. SO was supported by a USDA-NIFA predoctoral fellowship ( 012095-00002 ). DL was supported by Utrecht University and LettuceKnow project, project number 2.1 of the research Perspective Program P19-17 which is (partly) financed by the Dutch Research Council (NWO) and the breeding companies BASF, Bejo Zaden B.V., Limagrain, Enza Zaden Research & Development B.V., Rijk Zwaan Breeding B.V., Syngenta Seeds B.V., and Takii and Company Ltd. Figures were prepared with BioRender.com . We thank Jane E. Parker (Max Planck Institute for Plant Breeding Research, Germany) and Johnathan D. Jones (The Sainsbury Laboratory, the United Kingdom) for their expert opinions shown in the supplementary videos in this paper.

Funders	Funder number
Bejo Zaden B.V.
Bejo Zaden B.V. Limagrain
Enza Zaden Research & Development B.V. Rijk Zwaan Breeding B.V. Syngenta Seeds B.V.
Max Planck Institute for Plant Breeding Research
Rijk Zwaan Breeding B.V.
Sainsbury Laboratory
Syngenta Crop Protection, LLC
Syngenta Seeds B.V.
National Science Foundation	IOS-1758400
BASF
National Institute of Food and Agriculture	012095-00002
Universiteit Utrecht	P19-17
Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Keywords

Plant immune system
Innate immunity
Toll/interleukin-1 receptor (TIR)
Cell non-autonomous immunity
Crop improvement

Access to Document

10.1016/j.pbi.2023.102481Licence: CC BY

1-s2.0-S1369526623001462-mainFinal published version, 1.51 MBLicence: CC BY

Cite this

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title = "Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential",

abstract = "Across the Tree of Life, innate immunity and cell death mechanisms protect hosts from potential pathogens. In prokaryotes, animals, and flowering plants, these functions are often mediated by Toll/interleukin-1 receptor (TIR) domain proteins. Here, we discuss recent analyses of TIR biology in flowering plants, revealing (i) TIR functions beyond pathogen recognition, e.g. in the spatial control of immunity, and (ii) the existence of at least two pathways for TIR signaling in plants. Also, we discuss TIR-based strategies for crop improvement and argue for a need to better understand TIR functions outside of commonly studied dicot pathways for future translational work. Opinions of experts on emerging topics in basic and translational plant TIR research are presented in supplementary video interviews.",

keywords = "Plant immune system, Innate immunity, Toll/interleukin-1 receptor (TIR), Cell non-autonomous immunity, Crop improvement",

author = "Ogden, {Sam C.} and Nishimura, {Marc T.} and Dmitry Lapin",

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