Function prediction and protein networks

Martijn A. Huynen, Berend Snel, Christian Von Mering, Peer Bork

Research output: Contribution to journalBook/Film/Article reviewAcademic


In the genomics era, the interactions between proteins are at the center of attention. Genomic-context methods used to predict these interactions have been put on a quantitative basis, revealing that they are at least on an equal footing with genomics experimental data. A survey of experimentally confirmed predictions proves the applicability of these methods, and new concepts to predict protein interactions in eukaryotes have been described. Finally, the interaction networks that can be obtained by combining the predicted pair-wise interactions have enough internal structure to detect higher levels of organization, such as 'functional modules'.
Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number2
Publication statusPublished - 1 Apr 2003


  • frataxin
  • accuracy
  • eukaryote
  • genomics
  • nonhuman
  • prediction
  • priority journal
  • protein function
  • protein interaction
  • quantitative analysis
  • review
  • sequence homology


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