Four methods for general anaesthesia in the rabbit: a comparative study

M E Peeters; D Gil; E Teske; V Eyzenbach; W E vd Brom; J T Lumeij; H W de Vries

doi:10.1258/002367788780746197

Four methods for general anaesthesia in the rabbit: a comparative study

M E Peeters, D Gil, E Teske, V Eyzenbach, W E vd Brom, J T Lumeij, H W de Vries

Afd Marine and Atmospheric Research

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The efficacy and safety of pentobarbitone, ketamine/xylazine, fentanyl/fluanisone/diazepam, and halothane/nitrous oxide anaesthesia were compared in 4 groups of six New Zealand White rabbits. Heart and respiratory rates, body temperature, reflexes, blood pressure and blood gases were measured. Pentobarbitone appeared to be unsuitable for anaesthesia in rabbits, as 5 of the 6 rabbits to whom it was administered, required artificial respiration or died. The combinations of ketamine/xylazine and fentanyl-fluanisone/diazepam both produced unpredictable levels of anaesthesia together with a substantial decline in arterial blood pressure and PO2. Despite a severe drop in blood pressure (up to 37.5%), anaesthesia with halothane and nitrous oxide was found to be superior to the other anaesthetic agents.

Original language	English
Pages (from-to)	355-60
Number of pages	6
Journal	Laboratory Animals
Volume	22
Issue number	4
DOIs	https://doi.org/10.1258/002367788780746197
Publication status	Published - 1988

Keywords

Anesthesia, General/methods
Anesthesia, Inhalation/veterinary
Anesthetics, Dissociative/pharmacology
Animals
Barbiturates/pharmacology
Fentanyl/pharmacology
Male
Muscle Relaxation/drug effects
Rabbits/physiology

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10.1258/002367788780746197

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title = "Four methods for general anaesthesia in the rabbit: a comparative study",

abstract = "The efficacy and safety of pentobarbitone, ketamine/xylazine, fentanyl/fluanisone/diazepam, and halothane/nitrous oxide anaesthesia were compared in 4 groups of six New Zealand White rabbits. Heart and respiratory rates, body temperature, reflexes, blood pressure and blood gases were measured. Pentobarbitone appeared to be unsuitable for anaesthesia in rabbits, as 5 of the 6 rabbits to whom it was administered, required artificial respiration or died. The combinations of ketamine/xylazine and fentanyl-fluanisone/diazepam both produced unpredictable levels of anaesthesia together with a substantial decline in arterial blood pressure and PO2. Despite a severe drop in blood pressure (up to 37.5%), anaesthesia with halothane and nitrous oxide was found to be superior to the other anaesthetic agents.",

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author = "Peeters, {M E} and D Gil and E Teske and V Eyzenbach and {vd Brom}, {W E} and Lumeij, {J T} and {de Vries}, {H W}",

year = "1988",

doi = "10.1258/002367788780746197",

language = "English",

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T1 - Four methods for general anaesthesia in the rabbit

T2 - a comparative study

AU - Peeters, M E

AU - Gil, D

AU - Teske, E

AU - Eyzenbach, V

AU - vd Brom, W E

AU - Lumeij, J T

AU - de Vries, H W

PY - 1988

Y1 - 1988

N2 - The efficacy and safety of pentobarbitone, ketamine/xylazine, fentanyl/fluanisone/diazepam, and halothane/nitrous oxide anaesthesia were compared in 4 groups of six New Zealand White rabbits. Heart and respiratory rates, body temperature, reflexes, blood pressure and blood gases were measured. Pentobarbitone appeared to be unsuitable for anaesthesia in rabbits, as 5 of the 6 rabbits to whom it was administered, required artificial respiration or died. The combinations of ketamine/xylazine and fentanyl-fluanisone/diazepam both produced unpredictable levels of anaesthesia together with a substantial decline in arterial blood pressure and PO2. Despite a severe drop in blood pressure (up to 37.5%), anaesthesia with halothane and nitrous oxide was found to be superior to the other anaesthetic agents.

AB - The efficacy and safety of pentobarbitone, ketamine/xylazine, fentanyl/fluanisone/diazepam, and halothane/nitrous oxide anaesthesia were compared in 4 groups of six New Zealand White rabbits. Heart and respiratory rates, body temperature, reflexes, blood pressure and blood gases were measured. Pentobarbitone appeared to be unsuitable for anaesthesia in rabbits, as 5 of the 6 rabbits to whom it was administered, required artificial respiration or died. The combinations of ketamine/xylazine and fentanyl-fluanisone/diazepam both produced unpredictable levels of anaesthesia together with a substantial decline in arterial blood pressure and PO2. Despite a severe drop in blood pressure (up to 37.5%), anaesthesia with halothane and nitrous oxide was found to be superior to the other anaesthetic agents.

KW - Anesthesia, General/methods

KW - Anesthesia, Inhalation/veterinary

KW - Anesthetics, Dissociative/pharmacology

KW - Animals

KW - Barbiturates/pharmacology

KW - Fentanyl/pharmacology

KW - Male

KW - Muscle Relaxation/drug effects

KW - Rabbits/physiology

U2 - 10.1258/002367788780746197

DO - 10.1258/002367788780746197

M3 - Article

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SN - 0023-6772

VL - 22

SP - 355

EP - 360

JO - Laboratory Animals

JF - Laboratory Animals

IS - 4

ER -

Four methods for general anaesthesia in the rabbit: a comparative study

Abstract

Keywords

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