TY - JOUR
T1 - Food allergy and food-based therapies in neurodevelopmental disorders
AU - De Theije, Caroline G M
AU - Bavelaar, Bas M.
AU - Lopes da Silva, Sofia
AU - Korte, Sijmen Mechiel
AU - Olivier, Berend
AU - Garssen, Johan
AU - Kraneveld, Aletta D.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are neurodevelopmental disorders which occur in childhood and may persist into adulthood. Although the etiology of these disorders is largely unknown, genetic and environmental factors are thought to play a role in the development of ASD and ADHD. Allergic immune reactions, in prenatal and postnatal phases, are examples of these environmental factors, and adverse reactions to foods are reported in these children. In this review, we address the clinical and preclinical findings of (food) allergy in ASD and ADHD and suggest possible underlying mechanisms. Furthermore, opportunities for nutritional interventions in neurodevelopmental disorders are provided.
AB - Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are neurodevelopmental disorders which occur in childhood and may persist into adulthood. Although the etiology of these disorders is largely unknown, genetic and environmental factors are thought to play a role in the development of ASD and ADHD. Allergic immune reactions, in prenatal and postnatal phases, are examples of these environmental factors, and adverse reactions to foods are reported in these children. In this review, we address the clinical and preclinical findings of (food) allergy in ASD and ADHD and suggest possible underlying mechanisms. Furthermore, opportunities for nutritional interventions in neurodevelopmental disorders are provided.
KW - Attention deficit hyperactivity disorder
KW - Autism spectrum disorder
KW - Food allergy
KW - Food-based therapy
KW - Gut-brain axis
KW - Neurodevelopment
UR - http://www.scopus.com/inward/record.url?scp=84898829903&partnerID=8YFLogxK
U2 - 10.1111/pai.12149
DO - 10.1111/pai.12149
M3 - Article
AN - SCOPUS:84898829903
SN - 0905-6157
VL - 25
SP - 218
EP - 226
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 3
ER -