FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded

J Prilusky; CE Felder; T Zeev-Ben-Mordehai; EH Rydberg; O Man; J.S. Beckmann; I. Silman; J.L. Sussman

doi:10.1093/bioinformatics/bti537

FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded

J Prilusky, CE Felder, T Zeev-Ben-Mordehai, EH Rydberg, O Man, J.S. Beckmann, I. Silman, J.L. Sussman

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

Original language	English
Pages (from-to)	3435-3438
Number of pages	4
Journal	Bioinformatics
Volume	21
Issue number	16
DOIs	https://doi.org/10.1093/bioinformatics/bti537
Publication status	Published - 15 Aug 2005
Externally published	Yes

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title = "FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded",

abstract = " An easy-to-use, versatile and freely available graphic web server, FoldIndex{\textcopyright} is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex{\textcopyright} has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.",

author = "J Prilusky and CE Felder and T Zeev-Ben-Mordehai and EH Rydberg and O Man and J.S. Beckmann and I. Silman and J.L. Sussman",

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AU - Felder, CE

AU - Zeev-Ben-Mordehai, T

AU - Rydberg, EH

AU - Man, O

AU - Beckmann, J.S.

AU - Silman, I.

AU - Sussman, J.L.

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AB - An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

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DO - 10.1093/bioinformatics/bti537

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JO - Bioinformatics

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FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded

Abstract

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