Fish-meal diet enriched with omega-3 PUFA and treatment of canine chronic enteropathies

Edgar Corneille Ontsouka*, Iwan Anton Burgener, Nicole Luckschander-Zeller, Juerg Walter Blum, Christiane Albrecht

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The effects of a fish-meal- and potato-protein-based diet enriched with omega-3 PUFA on intestinal inflammatory activity and expression of genes active in fatty acid (FA) uptake were tested in the duodenum of dogs with food responsive diarrhea (FRD; n?=?14) and inflammatory bowel disease (IBD; n?=?7). The clinical outcome was estimated by monitoring the canine IBD activity index (CIBDAI) before and after treatment. Dogs were treated with the diet alone (FRD) or the diet in combination with immunosuppressants (IBD). The duodenal mRNA levels of FA translocase, FA transport protein-1,-3,-4,-6, long chain acyl coenzyme synthetase-1,-4,-5,-6, liver- and intestinal-FA binding proteins, interleukin-1 beta (IL)-1 beta and -6, and tumor necrosis factor-a were measured by quantitative PCR. The CIBDAI significantly decreased after treatment in all dogs. The mRNA levels of target genes were associated both with disease phenotype and dietary treatment. Significantly different expression patterns were found for IL-1 beta, FA translocase, intestinal-FA binding protein, FA transport proteins-1,-3,-6, and long chain acyl coenzyme synthetase-5,-6. In conclusion, the mRNA levels of some of the genes involved in duodenal FA uptake may be altered by a fish-meal- and potato-protein-based diet enriched with omega-3 PUFA. This may be beneficial for the treatment of canine chronic enteropathies, particularly FRD.

    Original languageEnglish
    Pages (from-to)412-422
    Number of pages11
    JournalEuropean Journal of Lipid Science and Technology
    Volume114
    Issue number4
    DOIs
    Publication statusPublished - Apr 2012

    Keywords

    • Canine inflammatory bowel disease index activity
    • Fatty acid transporters
    • Intestinal bowel disease
    • Omega-6 and omega-3 fatty acids
    • INFLAMMATORY-BOWEL-DISEASE
    • ACID-BINDING PROTEINS
    • POLYUNSATURATED FATTY-ACIDS
    • MESSENGER-RNA EXPRESSION
    • ACYL-COA SYNTHETASE
    • CHOLESTEROL UPTAKE
    • CELLULAR UPTAKE
    • DOGS
    • INTESTINE
    • METABOLISM

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