Fern genomes elucidate land plant evolution and cyanobacterial symbioses

Fay Wei Li*, Paul Brouwer, Lorenzo Carretero-Paulet, Shifeng Cheng, Jan De Vries, Pierre Marc Delaux, Ariana Eily, Nils Koppers, Li Yaung Kuo, Zheng Li, Mathew Simenc, Ian Small, Eric Wafula, Stephany Angarita, Michael S. Barker, Andrea Bräutigam, Claude Depamphilis, Sven Gould, Prashant S. Hosmani, Yao Moan HuangBruno Huettel, Yoichiro Kato, Xin Liu, Steven Maere, Rose McDowell, Lukas A. Mueller, Klaas G.J. Nierop, Stefan A. Rensing, Tanner Robison, Carl J. Rothfels, Erin M. Sigel, Yue Song, Prakash R. Timilsena, Yves Van De Peer, Hongli Wang, Per K.I. Wilhelmsson, Paul G. Wolf, Xun Xu, Joshua P. Der, Henriette Schluepmann, Gane K.S. Wong, Kathleen M. Pryer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Ferns are the closest sister group to all seed plants, yet little is known about their genomes other than that they are generally colossal. Here, we report on the genomes of Azolla filiculoides and Salvinia cucullata (Salviniales) and present evidence for episodic whole-genome duplication in ferns - one at the base of 'core leptosporangiates' and one specific to Azolla. One fern-specific gene that we identified, recently shown to confer high insect resistance, seems to have been derived from bacteria through horizontal gene transfer. Azolla coexists in a unique symbiosis with N2-fixing cyanobacteria, and we demonstrate a clear pattern of cospeciation between the two partners. Furthermore, the Azolla genome lacks genes that are common to arbuscular mycorrhizal and root nodule symbioses, and we identify several putative transporter genes specific to Azolla-cyanobacterial symbiosis. These genomic resources will help in exploring the biotechnological potential of Azolla and address fundamental questions in the evolution of plant life.

Original languageEnglish
Pages (from-to)460-472
Number of pages13
JournalNature Plants
Issue number7
Publication statusPublished - 2 Jul 2018


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