Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder

Maartje F Aukes; Wijnand Laan; Fabian Termorshuizen; Jacobine E Buizer-Voskamp; Eric A M Hennekam; Hugo M Smeets; Roel A Ophoff; Marco P M Boks; René S Kahn; M.F. Aukes

doi:10.1016/gim.2011.16

Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder

Maartje F Aukes, Wijnand Laan, Fabian Termorshuizen, Jacobine E Buizer-Voskamp, Eric A M Hennekam, Hugo M Smeets, Roel A Ophoff, Marco P M Boks, René S Kahn, M.F. Aukes

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder.

METHODS: Combining data from a psychiatric case registry and Statistics Netherlands provided information on 4,673 affected probands and 18,692 matched population controls.

RESULTS: Probands with schizophrenia had relative risks (RRs) for having a sibling with schizophrenia of 3.77 (95% confidence interval (CI): 2.60-5.46) and with bipolar disorder of 1.79 (95% CI: 0.64-4.96) as compared with a reference proband. Probands affected with bipolar disorder have an RR of 6.51 (95% CI: 2.60-16.29) for having a sibling with bipolar disorder and of 1.71 (95% CI: 0.71-4.14) for having a sibling with schizophrenia as compared with a reference proband. Probands affected with major depressive disorder also have increased risk for having a sibling with schizophrenia (RR: 2.04, 95% CI: 1.54-2.72) as compared with a reference proband, which was similar to the risk for having a sibling with major depressive disorder (RR: 1.91, 95% CI: 1.63-2.24) or bipolar disorder (RR: 2.06, 95% CI: 1.18-3.60).

CONCLUSION: Our findings suggest, as previous studies have, that risk across schizophrenia and bipolar disorder is considerably lower (twofold) than within diagnostic entities, whereas for major depressive disorder risk is similar within and across diagnostic entities.

Original language	English
Pages (from-to)	338-41
Number of pages	4
Journal	Genetics in Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/gim.2011.16
Publication status	Published - 2012

Keywords

Adult
Age Factors
Bipolar Disorder
Cluster Analysis
Depressive Disorder, Major
Family Health
Female
Humans
Male
Middle Aged
Netherlands
Risk
Schizophrenia
Sex Factors
Young Adult

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10.1016/gim.2011.16

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title = "Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder",

abstract = "PURPOSE: To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder.METHODS: Combining data from a psychiatric case registry and Statistics Netherlands provided information on 4,673 affected probands and 18,692 matched population controls.RESULTS: Probands with schizophrenia had relative risks (RRs) for having a sibling with schizophrenia of 3.77 (95% confidence interval (CI): 2.60-5.46) and with bipolar disorder of 1.79 (95% CI: 0.64-4.96) as compared with a reference proband. Probands affected with bipolar disorder have an RR of 6.51 (95% CI: 2.60-16.29) for having a sibling with bipolar disorder and of 1.71 (95% CI: 0.71-4.14) for having a sibling with schizophrenia as compared with a reference proband. Probands affected with major depressive disorder also have increased risk for having a sibling with schizophrenia (RR: 2.04, 95% CI: 1.54-2.72) as compared with a reference proband, which was similar to the risk for having a sibling with major depressive disorder (RR: 1.91, 95% CI: 1.63-2.24) or bipolar disorder (RR: 2.06, 95% CI: 1.18-3.60).CONCLUSION: Our findings suggest, as previous studies have, that risk across schizophrenia and bipolar disorder is considerably lower (twofold) than within diagnostic entities, whereas for major depressive disorder risk is similar within and across diagnostic entities.",

keywords = "Adult, Age Factors, Bipolar Disorder, Cluster Analysis, Depressive Disorder, Major, Family Health, Female, Humans, Male, Middle Aged, Netherlands, Risk, Schizophrenia, Sex Factors, Young Adult",

author = "Aukes, {Maartje F} and Wijnand Laan and Fabian Termorshuizen and Buizer-Voskamp, {Jacobine E} and Hennekam, {Eric A M} and Smeets, {Hugo M} and Ophoff, {Roel A} and Boks, {Marco P M} and Kahn, {Ren{\'e} S} and M.F. Aukes",

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doi = "10.1016/gim.2011.16",

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T1 - Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder

AU - Aukes, Maartje F

AU - Laan, Wijnand

AU - Termorshuizen, Fabian

AU - Buizer-Voskamp, Jacobine E

AU - Hennekam, Eric A M

AU - Smeets, Hugo M

AU - Ophoff, Roel A

AU - Boks, Marco P M

AU - Kahn, René S

AU - Aukes, M.F.

PY - 2012

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N2 - PURPOSE: To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder.METHODS: Combining data from a psychiatric case registry and Statistics Netherlands provided information on 4,673 affected probands and 18,692 matched population controls.RESULTS: Probands with schizophrenia had relative risks (RRs) for having a sibling with schizophrenia of 3.77 (95% confidence interval (CI): 2.60-5.46) and with bipolar disorder of 1.79 (95% CI: 0.64-4.96) as compared with a reference proband. Probands affected with bipolar disorder have an RR of 6.51 (95% CI: 2.60-16.29) for having a sibling with bipolar disorder and of 1.71 (95% CI: 0.71-4.14) for having a sibling with schizophrenia as compared with a reference proband. Probands affected with major depressive disorder also have increased risk for having a sibling with schizophrenia (RR: 2.04, 95% CI: 1.54-2.72) as compared with a reference proband, which was similar to the risk for having a sibling with major depressive disorder (RR: 1.91, 95% CI: 1.63-2.24) or bipolar disorder (RR: 2.06, 95% CI: 1.18-3.60).CONCLUSION: Our findings suggest, as previous studies have, that risk across schizophrenia and bipolar disorder is considerably lower (twofold) than within diagnostic entities, whereas for major depressive disorder risk is similar within and across diagnostic entities.

AB - PURPOSE: To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder.METHODS: Combining data from a psychiatric case registry and Statistics Netherlands provided information on 4,673 affected probands and 18,692 matched population controls.RESULTS: Probands with schizophrenia had relative risks (RRs) for having a sibling with schizophrenia of 3.77 (95% confidence interval (CI): 2.60-5.46) and with bipolar disorder of 1.79 (95% CI: 0.64-4.96) as compared with a reference proband. Probands affected with bipolar disorder have an RR of 6.51 (95% CI: 2.60-16.29) for having a sibling with bipolar disorder and of 1.71 (95% CI: 0.71-4.14) for having a sibling with schizophrenia as compared with a reference proband. Probands affected with major depressive disorder also have increased risk for having a sibling with schizophrenia (RR: 2.04, 95% CI: 1.54-2.72) as compared with a reference proband, which was similar to the risk for having a sibling with major depressive disorder (RR: 1.91, 95% CI: 1.63-2.24) or bipolar disorder (RR: 2.06, 95% CI: 1.18-3.60).CONCLUSION: Our findings suggest, as previous studies have, that risk across schizophrenia and bipolar disorder is considerably lower (twofold) than within diagnostic entities, whereas for major depressive disorder risk is similar within and across diagnostic entities.

KW - Adult

KW - Age Factors

KW - Bipolar Disorder

KW - Cluster Analysis

KW - Depressive Disorder, Major

KW - Family Health

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Netherlands

KW - Risk

KW - Schizophrenia

KW - Sex Factors

KW - Young Adult

U2 - 10.1016/gim.2011.16

DO - 10.1016/gim.2011.16

M3 - Article

C2 - 22241106

SN - 1098-3600

VL - 14

SP - 338

EP - 341

JO - Genetics in Medicine

JF - Genetics in Medicine

IS - 3

ER -

Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder

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Keywords

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