Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study

Matthaios Papadimitriou-Olivgeris; Nikolaos Giormezis; Fotini Fligou; Apostolos Liakopoulos; Markos Marangos; Evangelos D Anastassiou; Efthimia Petinaki; Kriton S Filos; Iris Spiliopoulou

doi:10.1159/000363281

Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study

Matthaios Papadimitriou-Olivgeris, Nikolaos Giormezis, Fotini Fligou, Apostolos Liakopoulos, Markos Marangos, Evangelos D Anastassiou, Efthimia Petinaki, Kriton S Filos, Iris Spiliopoulou^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit.

METHODS: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones.

RESULTS: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day.

CONCLUSIONS: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS.

Original language	English
Pages (from-to)	420-426
Number of pages	7
Journal	Chemotherapy
Volume	59
Issue number	6
DOIs	https://doi.org/10.1159/000363281
Publication status	Published - 2013
Externally published	Yes

Keywords

Acetamides/pharmacology
Adult
Aged
Anti-Bacterial Agents/pharmacology
Coagulase/genetics
Cohort Studies
Female
Humans
Intensive Care Units
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
Mutation
Oxazolidinones/pharmacology
Phenotype
RNA, Ribosomal, 23S/genetics
Retrospective Studies
Risk Factors
Staphylococcal Infections/drug therapy
Staphylococcus/drug effects

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10.1159/000363281

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Papadimitriou-Olivgeris, M., Giormezis, N., Fligou, F., Liakopoulos, A., Marangos, M., Anastassiou, E. D., Petinaki, E., Filos, K. S., & Spiliopoulou, I. (2013). Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study. Chemotherapy, 59(6), 420-426. https://doi.org/10.1159/000363281

@article{131026d3c0ee420c963552727727fd28,

title = "Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study",

abstract = "BACKGROUND: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit.METHODS: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones.RESULTS: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day.CONCLUSIONS: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS.",

keywords = "Acetamides/pharmacology, Adult, Aged, Anti-Bacterial Agents/pharmacology, Coagulase/genetics, Cohort Studies, Female, Humans, Intensive Care Units, Linezolid, Male, Microbial Sensitivity Tests, Middle Aged, Mutation, Oxazolidinones/pharmacology, Phenotype, RNA, Ribosomal, 23S/genetics, Retrospective Studies, Risk Factors, Staphylococcal Infections/drug therapy, Staphylococcus/drug effects",

author = "Matthaios Papadimitriou-Olivgeris and Nikolaos Giormezis and Fotini Fligou and Apostolos Liakopoulos and Markos Marangos and Anastassiou, {Evangelos D} and Efthimia Petinaki and Filos, {Kriton S} and Iris Spiliopoulou",

note = "{\textcopyright} 2014 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000363281",

language = "English",

volume = "59",

pages = "420--426",

journal = "Chemotherapy",

issn = "0009-3157",

publisher = "S. Karger AG",

number = "6",

}

Papadimitriou-Olivgeris, M, Giormezis, N, Fligou, F, Liakopoulos, A, Marangos, M, Anastassiou, ED, Petinaki, E, Filos, KS & Spiliopoulou, I 2013, 'Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study', Chemotherapy, vol. 59, no. 6, pp. 420-426. https://doi.org/10.1159/000363281

Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study. / Papadimitriou-Olivgeris, Matthaios; Giormezis, Nikolaos; Fligou, Fotini et al.
In: Chemotherapy, Vol. 59, No. 6, 2013, p. 420-426.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit

T2 - a retrospective cohort study

AU - Papadimitriou-Olivgeris, Matthaios

AU - Giormezis, Nikolaos

AU - Fligou, Fotini

AU - Liakopoulos, Apostolos

AU - Marangos, Markos

AU - Anastassiou, Evangelos D

AU - Petinaki, Efthimia

AU - Filos, Kriton S

AU - Spiliopoulou, Iris

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit.METHODS: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones.RESULTS: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day.CONCLUSIONS: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS.

AB - BACKGROUND: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit.METHODS: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones.RESULTS: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day.CONCLUSIONS: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS.

KW - Acetamides/pharmacology

KW - Adult

KW - Aged

KW - Anti-Bacterial Agents/pharmacology

KW - Coagulase/genetics

KW - Cohort Studies

KW - Female

KW - Humans

KW - Intensive Care Units

KW - Linezolid

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Mutation

KW - Oxazolidinones/pharmacology

KW - Phenotype

KW - RNA, Ribosomal, 23S/genetics

KW - Retrospective Studies

KW - Risk Factors

KW - Staphylococcal Infections/drug therapy

KW - Staphylococcus/drug effects

U2 - 10.1159/000363281

DO - 10.1159/000363281

M3 - Article

C2 - 25060224

SN - 0009-3157

VL - 59

SP - 420

EP - 426

JO - Chemotherapy

JF - Chemotherapy

IS - 6

ER -

Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study

Abstract

Keywords

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