TY - JOUR
T1 - Factors contributing to the variation in feline urinary oxalate excretion rate.
AU - Dijcker, Judith
AU - Hagen - Plantinga, Esther
AU - Everts, Henk
AU - Queau, Yann
AU - Biourge, Vincent
AU - Hendriks, Wouter
PY - 2014
Y1 - 2014
N2 - This study aimed to identify factors (season,
animal, and diet) contributing to the variation in
urinary oxalate (Uox) excretion rate, Uox concentration,
and urine volume in healthy adult cats. A data set
(1,940 observations) containing information on Uox
excretion rate of 65 cats fed 252 diets (i.e., each diet
was fed to a group of 6 to 8 cats), with known dietary
oxalate concentrations, collected over a 6 yr period at a
feline nutrition facility, were retrospectively analyzed.
Data related to season, animal (i.e., age, gender, body
weight, and breed), and diet (i.e., nutrient content)
characteristics were subjected to stepwise multivariate
regression analysis to identify factors significantly
correlated to Uox excretion rate (μmol/(kg BW0.67·d))
and concentration (mmol/L) as well as urine volume
(mL/(kg BW0.67·d)). Independent factors significantly
(P < 0.05) associated with lower Uox concentration
(mmol/L) included greater ash, Ca, and Na intake and
lower nitrogen-free extract, total dietary fiber, P, and
oxalate intake, and a body weight <5 kg. Factors significantly
associated with lower Uox excretion rate
(μmol/(kg BW0.67·d)) included greater crude fat and Ca
intake and lower CP, total dietary fiber, P, and oxalate
intake. However, a considerable part of the variation in
Uox excretion rate remained unexplained. The majority
of the unexplained variation in Uox excretion rate
is likely to be related to factors involved in endogenous
oxalate synthesis, as the majority of the dietary factors
involved in intestinal oxalate absorption were included
in the model. Apparent intestinal oxalate absorption
was estimated to be 6.2% on average; however, much
variation was present. Future research on Uox excretion
rate in cats should focus on the influence of dietary protein
sources, amino acid composition, vitamin C (that
was not included in the present study), and variations in
apparent intestinal oxalate absorption.
AB - This study aimed to identify factors (season,
animal, and diet) contributing to the variation in
urinary oxalate (Uox) excretion rate, Uox concentration,
and urine volume in healthy adult cats. A data set
(1,940 observations) containing information on Uox
excretion rate of 65 cats fed 252 diets (i.e., each diet
was fed to a group of 6 to 8 cats), with known dietary
oxalate concentrations, collected over a 6 yr period at a
feline nutrition facility, were retrospectively analyzed.
Data related to season, animal (i.e., age, gender, body
weight, and breed), and diet (i.e., nutrient content)
characteristics were subjected to stepwise multivariate
regression analysis to identify factors significantly
correlated to Uox excretion rate (μmol/(kg BW0.67·d))
and concentration (mmol/L) as well as urine volume
(mL/(kg BW0.67·d)). Independent factors significantly
(P < 0.05) associated with lower Uox concentration
(mmol/L) included greater ash, Ca, and Na intake and
lower nitrogen-free extract, total dietary fiber, P, and
oxalate intake, and a body weight <5 kg. Factors significantly
associated with lower Uox excretion rate
(μmol/(kg BW0.67·d)) included greater crude fat and Ca
intake and lower CP, total dietary fiber, P, and oxalate
intake. However, a considerable part of the variation in
Uox excretion rate remained unexplained. The majority
of the unexplained variation in Uox excretion rate
is likely to be related to factors involved in endogenous
oxalate synthesis, as the majority of the dietary factors
involved in intestinal oxalate absorption were included
in the model. Apparent intestinal oxalate absorption
was estimated to be 6.2% on average; however, much
variation was present. Future research on Uox excretion
rate in cats should focus on the influence of dietary protein
sources, amino acid composition, vitamin C (that
was not included in the present study), and variations in
apparent intestinal oxalate absorption.
KW - cats
KW - diet
KW - feline
KW - urinary oxalate
KW - urolithiasis
U2 - 10.2527/jas2012-5672
DO - 10.2527/jas2012-5672
M3 - Article
SN - 0021-8812
VL - 92
SP - 1029
EP - 1036
JO - Journal of Animal Science
JF - Journal of Animal Science
IS - 3
ER -