Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area

C C H Wielders; A H A M van Hoek; P D Hengeveld; C Veenman; C M Dierikx; T P Zomer; L A M Smit; W van der Hoek; D J Heederik; S C de Greeff; C B M Maassen; E van Duijkeren

doi:10.1016/j.cmi.2016.10.013

Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area

C C H Wielders, A H A M van Hoek, P D Hengeveld, C Veenman, C M Dierikx, T P Zomer, L A M Smit, W van der Hoek, D J Heederik, S C de Greeff, C B M Maassen, E van Duijkeren

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of ESBL/pAmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E.

METHODS: A cross-sectional study was performed among 2,432 adults (aged 20-72 years) in twelve temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression.

RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2,432; 95%CI: 3.7-5.4) ranging from 1.4-10.9% among the research centres. ESBL/pAmpC resistance genes were detected in E. coli and K. pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were blaCTX-M-15, blaCTX-M-14/17, and blaCTX-M-1, originating from 76 participants. Travel in the last twelve months to Africa, Asia or Latin America (OR: 2.82 (95%CI: 1.71-4.63)), having kept cows for a hobby (last five years) (OR: 3.77 (95%CI: 1.22-11.64)), usage of proton-pump inhibitors (OR: 1.84 (95%CI: 1.05-3.23)), and living within 1,000 metres of a mink farm (OR: 2.26 (95%CI: 1.28-3.98)) were identified as risk factors. Exposure to poultry was not identified as a risk factor.

CONCLUSIONS: Overall, living in close proximity of livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.

Original language	English
Article number	120
Pages (from-to)	120.e1–120.e8
Journal	Clinical Microbiology and Infection
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.cmi.2016.10.013
Publication status	Published - 2017

Keywords

AmpC
Antimicrobial resistance
Environment
Extended-spectrum β-lactamases
β-lactam resistance
Livestock farming
Prevalence
Risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmi.2016.10.013

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Wielders, C. C. H., van Hoek, A. H. A. M., Hengeveld, P. D., Veenman, C., Dierikx, C. M., Zomer, T. P., Smit, L. A. M., van der Hoek, W., Heederik, D. J., de Greeff, S. C., Maassen, C. B. M., & van Duijkeren, E. (2017). Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area. Clinical Microbiology and Infection, 23(2), 120.e1–120.e8. Article 120. https://doi.org/10.1016/j.cmi.2016.10.013

@article{cc3052e9a82148669a63142aae4b5037,

title = "Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area",

abstract = "OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of ESBL/pAmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E.METHODS: A cross-sectional study was performed among 2,432 adults (aged 20-72 years) in twelve temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression.RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2,432; 95%CI: 3.7-5.4) ranging from 1.4-10.9% among the research centres. ESBL/pAmpC resistance genes were detected in E. coli and K. pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were blaCTX-M-15, blaCTX-M-14/17, and blaCTX-M-1, originating from 76 participants. Travel in the last twelve months to Africa, Asia or Latin America (OR: 2.82 (95%CI: 1.71-4.63)), having kept cows for a hobby (last five years) (OR: 3.77 (95%CI: 1.22-11.64)), usage of proton-pump inhibitors (OR: 1.84 (95%CI: 1.05-3.23)), and living within 1,000 metres of a mink farm (OR: 2.26 (95%CI: 1.28-3.98)) were identified as risk factors. Exposure to poultry was not identified as a risk factor.CONCLUSIONS: Overall, living in close proximity of livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.",

keywords = "AmpC, Antimicrobial resistance, Environment, Extended-spectrum β-lactamases, β-lactam resistance, Livestock farming, Prevalence, Risk factors",

author = "Wielders, {C C H} and {van Hoek}, {A H A M} and Hengeveld, {P D} and C Veenman and Dierikx, {C M} and Zomer, {T P} and Smit, {L A M} and {van der Hoek}, W and Heederik, {D J} and {de Greeff}, {S C} and Maassen, {C B M} and {van Duijkeren}, E",

year = "2017",

doi = "10.1016/j.cmi.2016.10.013",

language = "English",

volume = "23",

pages = "120.e1–120.e8",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier BV",

number = "2",

}

Wielders, CCH, van Hoek, AHAM, Hengeveld, PD, Veenman, C, Dierikx, CM, Zomer, TP, Smit, LAM, van der Hoek, W, Heederik, DJ, de Greeff, SC, Maassen, CBM & van Duijkeren, E 2017, 'Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area', Clinical Microbiology and Infection, vol. 23, no. 2, 120, pp. 120.e1–120.e8. https://doi.org/10.1016/j.cmi.2016.10.013

TY - JOUR

T1 - Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area

AU - Wielders, C C H

AU - van Hoek, A H A M

AU - Hengeveld, P D

AU - Veenman, C

AU - Dierikx, C M

AU - Zomer, T P

AU - Smit, L A M

AU - van der Hoek, W

AU - Heederik, D J

AU - de Greeff, S C

AU - Maassen, C B M

AU - van Duijkeren, E

PY - 2017

Y1 - 2017

N2 - OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of ESBL/pAmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E.METHODS: A cross-sectional study was performed among 2,432 adults (aged 20-72 years) in twelve temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression.RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2,432; 95%CI: 3.7-5.4) ranging from 1.4-10.9% among the research centres. ESBL/pAmpC resistance genes were detected in E. coli and K. pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were blaCTX-M-15, blaCTX-M-14/17, and blaCTX-M-1, originating from 76 participants. Travel in the last twelve months to Africa, Asia or Latin America (OR: 2.82 (95%CI: 1.71-4.63)), having kept cows for a hobby (last five years) (OR: 3.77 (95%CI: 1.22-11.64)), usage of proton-pump inhibitors (OR: 1.84 (95%CI: 1.05-3.23)), and living within 1,000 metres of a mink farm (OR: 2.26 (95%CI: 1.28-3.98)) were identified as risk factors. Exposure to poultry was not identified as a risk factor.CONCLUSIONS: Overall, living in close proximity of livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.

AB - OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of ESBL/pAmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E.METHODS: A cross-sectional study was performed among 2,432 adults (aged 20-72 years) in twelve temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression.RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2,432; 95%CI: 3.7-5.4) ranging from 1.4-10.9% among the research centres. ESBL/pAmpC resistance genes were detected in E. coli and K. pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were blaCTX-M-15, blaCTX-M-14/17, and blaCTX-M-1, originating from 76 participants. Travel in the last twelve months to Africa, Asia or Latin America (OR: 2.82 (95%CI: 1.71-4.63)), having kept cows for a hobby (last five years) (OR: 3.77 (95%CI: 1.22-11.64)), usage of proton-pump inhibitors (OR: 1.84 (95%CI: 1.05-3.23)), and living within 1,000 metres of a mink farm (OR: 2.26 (95%CI: 1.28-3.98)) were identified as risk factors. Exposure to poultry was not identified as a risk factor.CONCLUSIONS: Overall, living in close proximity of livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.

KW - AmpC

KW - Antimicrobial resistance

KW - Environment

KW - Extended-spectrum β-lactamases

KW - β-lactam resistance

KW - Livestock farming

KW - Prevalence

KW - Risk factors

U2 - 10.1016/j.cmi.2016.10.013

DO - 10.1016/j.cmi.2016.10.013

M3 - Article

C2 - 27773759

SN - 1198-743X

VL - 23

SP - 120.e1–120.e8

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 2

M1 - 120

ER -

Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area

Abstract

Keywords

UN SDGs

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