Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft; Virissa Lenters; Roel Vermeulen; Dick Heederik; Cathrine Thomsen; Georg Becher; Aleksander Giwercman; Davide Bizzaro; Gian Carlo Manicardi; Marcello Spano; Lars Rylander; Henning S. Pedersen; Pawel Strucinski; Valentyna Zviezdai; Jens Peter Bonde

doi:10.1016/j.reprotox.2013.10.002

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft^*, Virissa Lenters, Roel Vermeulen, Dick Heederik, Cathrine Thomsen, Georg Becher, Aleksander Giwercman, Davide Bizzaro, Gian Carlo Manicardi, Marcello Spano, Lars Rylander, Henning S. Pedersen, Pawel Strucinski, Valentyna Zviezdai, Jens Peter Bonde

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (C) 2013 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Reproductive Toxicology
Volume	43
DOIs	https://doi.org/10.1016/j.reprotox.2013.10.002
Publication status	Published - Jan 2014

Funding

The data on male fertility was collected as part of the INUENDO study (www.inuendo.dk) funded by the European Commission's 5th Framework Program (QLK4-CT-2001-00202). Determination of PBDEs in serum and data analyses were part of the CLEAR study (www.inuendo.dk/clear) supported by the European Commission's 7th Framework Program (FP7-ENV-2008-1-226217).

Keywords

Semen quality
Reproductive hormones
Inhibin B
DNA damage
Apoptosis
PBDE
BDE-47
BDE-153
BROMINATED FLAME RETARDANTS
SPERM CHROMATIN INTEGRITY
IN-HOUSE DUST
SEMEN QUALITY
SERUM-LEVELS
DNA FRAGMENTATION
INUIT POPULATIONS
HORMONE-LEVELS
BIPHENYL PBB
MEN

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Toft, G., Lenters, V., Vermeulen, R., Heederik, D., Thomsen, C., Becher, G., Giwercman, A., Bizzaro, D., Manicardi, G. C., Spano, M., Rylander, L., Pedersen, H. S., Strucinski, P., Zviezdai, V., & Bonde, J. P. (2014). Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine. Reproductive Toxicology, 43, 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

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abstract = "Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (C) 2013 Elsevier Inc. All rights reserved.",

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author = "Gunnar Toft and Virissa Lenters and Roel Vermeulen and Dick Heederik and Cathrine Thomsen and Georg Becher and Aleksander Giwercman and Davide Bizzaro and Manicardi, {Gian Carlo} and Marcello Spano and Lars Rylander and Pedersen, {Henning S.} and Pawel Strucinski and Valentyna Zviezdai and Bonde, {Jens Peter}",

year = "2014",

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doi = "10.1016/j.reprotox.2013.10.002",

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Toft, G, Lenters, V, Vermeulen, R , Heederik, D, Thomsen, C, Becher, G, Giwercman, A, Bizzaro, D, Manicardi, GC, Spano, M, Rylander, L, Pedersen, HS, Strucinski, P, Zviezdai, V & Bonde, JP 2014, 'Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine', Reproductive Toxicology, vol. 43, pp. 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

TY - JOUR

T1 - Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

AU - Toft, Gunnar

AU - Lenters, Virissa

AU - Vermeulen, Roel

AU - Heederik, Dick

AU - Thomsen, Cathrine

AU - Becher, Georg

AU - Giwercman, Aleksander

AU - Bizzaro, Davide

AU - Manicardi, Gian Carlo

AU - Spano, Marcello

AU - Rylander, Lars

AU - Pedersen, Henning S.

AU - Strucinski, Pawel

AU - Zviezdai, Valentyna

AU - Bonde, Jens Peter

PY - 2014/1

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N2 - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (C) 2013 Elsevier Inc. All rights reserved.

AB - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (C) 2013 Elsevier Inc. All rights reserved.

KW - Semen quality

KW - Reproductive hormones

KW - Inhibin B

KW - DNA damage

KW - Apoptosis

KW - PBDE

KW - BDE-47

KW - BDE-153

KW - BROMINATED FLAME RETARDANTS

KW - SPERM CHROMATIN INTEGRITY

KW - IN-HOUSE DUST

KW - SEMEN QUALITY

KW - SERUM-LEVELS

KW - DNA FRAGMENTATION

KW - INUIT POPULATIONS

KW - HORMONE-LEVELS

KW - BIPHENYL PBB

KW - MEN

U2 - 10.1016/j.reprotox.2013.10.002

DO - 10.1016/j.reprotox.2013.10.002

M3 - Article

SN - 0890-6238

VL - 43

SP - 1

EP - 7

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Abstract

Funding

Keywords

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