TY - JOUR
T1 - Exposure to Medical Radiation during Fetal Life, Childhood and Adolescence and Risk of Brain Tumor in Young Age
T2 - Results from the MOBI-Kids Case-Control Study
AU - Pasqual, Elisa
AU - Castanõ-Vinyals, Gemma
AU - Thierry-Chef, Isabelle
AU - Kojimahara, Noriko
AU - Sim, Malcolm R.
AU - Kundi, Michael
AU - Krewski, Daniel
AU - Momoli, Franco
AU - Lacour, Brigitte
AU - Remen, Thomas
AU - Radon, Katja
AU - Weinmann, Tobias
AU - Petridou, Eleni
AU - Moschovi, Maria
AU - Dikshit, Rajesh
AU - Sadetski, Siegal
AU - Maule, Milena
AU - Farinotti, Mariangela
AU - Ha, Mina
AU - T'Mannetje, Andrea
AU - Alguacil, Juan
AU - Aragonés, Nuria
AU - Vermeulen, Roel
AU - Kromhout, Hans
AU - Cardis, Elisabeth
PY - 2020/7
Y1 - 2020/7
N2 - Background: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. Methods: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. Results: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. Conclusions: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
AB - Background: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. Methods: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. Results: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. Conclusions: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
KW - Brain cancer
KW - Children-adolescent health
KW - Environmental Exposure
KW - Epidemiology studies
KW - Medical radiation
UR - http://www.scopus.com/inward/record.url?scp=85082533967&partnerID=8YFLogxK
U2 - 10.1159/000506131
DO - 10.1159/000506131
M3 - Article
C2 - 32200380
AN - SCOPUS:85082533967
SN - 0251-5350
VL - 54
SP - 343
EP - 355
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 4
ER -