Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Sander Kooijmans; Olivier G. de Jong; Raymond Schiffelers

doi:10.1016/j.addr.2021.03.017

Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Sander Kooijmans, Olivier G. de Jong, Raymond Schiffelers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins, nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another to modulate physiological and pathological processes. Due to their presumed biocompatibility and capacity to circumvent canonical delivery barriers encountered by synthetic drug delivery systems, EVs have attracted considerable interest as drug delivery vehicles. However, it is unclear which mechanisms and molecules orchestrate EV-mediated cargo delivery to recipient cells. Here, we review how EV properties have been exploited to improve the efficacy of small molecule drugs. Furthermore, we explore which EV surface molecules could be directly or indirectly involved in EV-mediated cargo transfer to recipient cells and discuss the cellular reporter systems with which such transfer can be studied. Finally, we elaborate on currently identified cellular processes involved in EV cargo delivery. Through these topics, we provide insights in critical effectors in the EV-cell interface which may be exploited in nature-inspired drug delivery strategies.

Original language	English
Pages (from-to)	252-278
Number of pages	27
Journal	Advanced Drug Delivery Reviews
Volume	173
DOIs	https://doi.org/10.1016/j.addr.2021.03.017
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
SAAK was supported by a Veni grant in the Applied and Engineering Sciences Domain of the Dutch Research Council (NWO)[grant number 17296]; OGJ was supported by a Veni grant in the Science. Domain of the Dutch Research Council (NWO) (grant number VI.Veni.192.174). RMS is supported by by the project B-SMART and EXPERT as part of the European Union's Horizon 2020 research and innovation programme under grant agreement No 721058 and 825858, respectively. Dr. Pieter Vader is thanked for fruitful discussions and valuable input for this review.

Publisher Copyright:
© 2021 The Authors

Keywords

Drug delivery
Exosomes
Extracellular vesicle surface
Extracellular vesicles
Protein delivery
RNA delivery
Reporter systems
Small molecules
Uptake mechanisms

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1-s2.0-S0169409X21000958-mainFinal published version, 1.39 MBLicence: CC BY-NC-ND

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title = "Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design",

abstract = "Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins, nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another to modulate physiological and pathological processes. Due to their presumed biocompatibility and capacity to circumvent canonical delivery barriers encountered by synthetic drug delivery systems, EVs have attracted considerable interest as drug delivery vehicles. However, it is unclear which mechanisms and molecules orchestrate EV-mediated cargo delivery to recipient cells. Here, we review how EV properties have been exploited to improve the efficacy of small molecule drugs. Furthermore, we explore which EV surface molecules could be directly or indirectly involved in EV-mediated cargo transfer to recipient cells and discuss the cellular reporter systems with which such transfer can be studied. Finally, we elaborate on currently identified cellular processes involved in EV cargo delivery. Through these topics, we provide insights in critical effectors in the EV-cell interface which may be exploited in nature-inspired drug delivery strategies.",

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author = "Sander Kooijmans and {de Jong}, {Olivier G.} and Raymond Schiffelers",

note = "Funding Information: SAAK was supported by a Veni grant in the Applied and Engineering Sciences Domain of the Dutch Research Council (NWO)[grant number 17296]; OGJ was supported by a Veni grant in the Science. Domain of the Dutch Research Council (NWO) (grant number VI.Veni.192.174). RMS is supported by by the project B-SMART and EXPERT as part of the European Union's Horizon 2020 research and innovation programme under grant agreement No 721058 and 825858, respectively. Dr. Pieter Vader is thanked for fruitful discussions and valuable input for this review. Publisher Copyright: {\textcopyright} 2021 The Authors",

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AU - Schiffelers, Raymond

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PY - 2021/6

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N2 - Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins, nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another to modulate physiological and pathological processes. Due to their presumed biocompatibility and capacity to circumvent canonical delivery barriers encountered by synthetic drug delivery systems, EVs have attracted considerable interest as drug delivery vehicles. However, it is unclear which mechanisms and molecules orchestrate EV-mediated cargo delivery to recipient cells. Here, we review how EV properties have been exploited to improve the efficacy of small molecule drugs. Furthermore, we explore which EV surface molecules could be directly or indirectly involved in EV-mediated cargo transfer to recipient cells and discuss the cellular reporter systems with which such transfer can be studied. Finally, we elaborate on currently identified cellular processes involved in EV cargo delivery. Through these topics, we provide insights in critical effectors in the EV-cell interface which may be exploited in nature-inspired drug delivery strategies.

AB - Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins, nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another to modulate physiological and pathological processes. Due to their presumed biocompatibility and capacity to circumvent canonical delivery barriers encountered by synthetic drug delivery systems, EVs have attracted considerable interest as drug delivery vehicles. However, it is unclear which mechanisms and molecules orchestrate EV-mediated cargo delivery to recipient cells. Here, we review how EV properties have been exploited to improve the efficacy of small molecule drugs. Furthermore, we explore which EV surface molecules could be directly or indirectly involved in EV-mediated cargo transfer to recipient cells and discuss the cellular reporter systems with which such transfer can be studied. Finally, we elaborate on currently identified cellular processes involved in EV cargo delivery. Through these topics, we provide insights in critical effectors in the EV-cell interface which may be exploited in nature-inspired drug delivery strategies.

KW - Drug delivery

KW - Exosomes

KW - Extracellular vesicle surface

KW - Extracellular vesicles

KW - Protein delivery

KW - RNA delivery

KW - Reporter systems

KW - Small molecules

KW - Uptake mechanisms

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U2 - 10.1016/j.addr.2021.03.017

DO - 10.1016/j.addr.2021.03.017

M3 - Review article

SN - 0169-409X

VL - 173

SP - 252

EP - 278

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Abstract

Bibliographical note

Keywords

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