Experimental Intraperitoneal Infection of Piglets

Milan Obradovic; Matheus de O. Costa

doi:10.1007/978-1-0716-3898-9_9

Experimental Intraperitoneal Infection of Piglets

Milan Obradovic, Matheus de O. Costa^*

^*Corresponding author for this work

University of Saskatchewan

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	2815
DOIs	https://doi.org/10.1007/978-1-0716-3898-9_9
Publication status	Published - 18 Jun 2024

Bibliographical note

Publisher Copyright:
© The Author(s).

Funding

VIDO receives operational funding from the Government of Saskatchewan through Innovation Saskatchewan and the Ministry of Agriculture and from the Canada Foundation for Innovation through the Major Science Initiatives Fund.

Funders	Funder number
Government of Saskatchewan
Ministry of Agriculture
Canada Foundation for Innovation

Keywords

Animal model
Challenge
Experimental
In vivo
Infection
Intraperitoneal
Model
Streptococcus suis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-0716-3898-9_9

978-1-0716-3898-9_9Final published version, 156 KBLicence: Taverne

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title = "Experimental Intraperitoneal Infection of Piglets",

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AU - Costa, Matheus de O.

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AB - Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.

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KW - Experimental

KW - In vivo

KW - Infection

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KW - Model

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JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Experimental Intraperitoneal Infection of Piglets

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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Erratum: Correction to: Experimental Intraperitoneal Infection of Piglets (Methods in molecular biology (Clifton, N.J.) (2024) 2815 DOI: 10.1007/978-1-0716-3898-9_9)

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