Experimental Intraperitoneal Infection of Piglets

Milan Obradovic; Matheus de O. Costa

doi:10.1007/978-1-0716-3898-9_9

Experimental Intraperitoneal Infection of Piglets

Milan Obradovic, Matheus de O. Costa^*

^*Corresponding author for this work

University of Saskatchewan

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	2815
DOIs	https://doi.org/10.1007/978-1-0716-3898-9_9
Publication status	Published - 18 Jun 2024

Keywords

Animal model
Challenge
Experimental
In vivo
Infection
Intraperitoneal
Model
Streptococcus suis

Access to Document

10.1007/978-1-0716-3898-9_9

Embargoed Document

978-1-0716-3898-9_9
Final published version, 156 KB
Licence: Taverne
Embargo ends: 18/12/24
Request copy

Cite this

@article{d13789b38d034ba28b877b4ad4901f17,

title = "Experimental Intraperitoneal Infection of Piglets",

abstract = "Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.",

keywords = "Animal model, Challenge, Experimental, In vivo, Infection, Intraperitoneal, Model, Streptococcus suis",

author = "Milan Obradovic and Costa, {Matheus de O.}",

note = "Publisher Copyright: {\textcopyright} The Author(s).",

year = "2024",

month = jun,

day = "18",

doi = "10.1007/978-1-0716-3898-9_9",

language = "English",

volume = "2815",

pages = "115--119",

journal = "Methods in molecular biology (Clifton, N.J.)",

issn = "1064-3745",

publisher = "Humana Press",

}

TY - JOUR

T1 - Experimental Intraperitoneal Infection of Piglets

AU - Obradovic, Milan

AU - Costa, Matheus de O.

N1 - Publisher Copyright: © The Author(s).

PY - 2024/6/18

Y1 - 2024/6/18

N2 - Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.

AB - Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.

KW - Animal model

KW - Challenge

KW - Experimental

KW - In vivo

KW - Infection

KW - Intraperitoneal

KW - Model

KW - Streptococcus suis

UR - http://www.scopus.com/inward/record.url?scp=85196455016&partnerID=8YFLogxK

U2 - 10.1007/978-1-0716-3898-9_9

DO - 10.1007/978-1-0716-3898-9_9

M3 - Article

C2 - 38884914

AN - SCOPUS:85196455016

SN - 1064-3745

VL - 2815

SP - 115

EP - 119

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Experimental Intraperitoneal Infection of Piglets

Abstract

Keywords

Access to Document

Embargoed Document

Fingerprint

Cite this