TY - JOUR
T1 - Evidence of cat-to-human transmission of Staphylococcus felis.
AU - Sips, Gregorius J
AU - van Dijk, Marloes A M
AU - van Westreenen, Mireille
AU - van der Graaf-van Bloois, Linda
AU - Duim, Birgitta
AU - Broens, Els M
N1 - Funding Information:
This work received no specific grant from any funding agency. The authors would like to thank the veterinarian from Veterinary Clinic Ridderkerk who sampled the three cats.
Publisher Copyright:
© 2023 The Authors.
PY - 2023/2/1
Y1 - 2023/2/1
N2 -
Introduction.
Staphylococcus felis is a coagulase-negative staphylococcal species that is commonly isolated from healthy cats. Like other commensal staphylococci,
S. felis can cause opportunistic infections, e.g. otitis externa, skin and urinary tract infections, in cats.
Gap Statement. Several studies have reported within-household transmission between humans and pets and human infections caused by coagulase-positive staphylococci. However, human infections with coagulase-negative staphylococci of zoonotic origin are relatively rare.
Methodology. Culture of a surgical site infection in a 58-year-old woman who underwent a laminectomy revealed dominant growth of
S. felis. The three cats owned by the patient were sampled to investigate potential within-household transmission.
S. felis isolates were sequenced to investigate the relatedness of the isolates and to look for virulence factors and host specific genes.
Results. All cats were colonized with
S. felis. Comparative genomics of the isolates showed that each cat was colonized with a distinct genotype. The patient's isolate clustered with isolates of one of the cats. Sequence analysis of the studied isolates together with 29 publicly available
S. felis genomes detected putative virulence factors that can be crucial in potential interspecies transmission.
Conclusion. The current case is the first reported human infection caused by
S. felis and highlights the zoonotic potential of this bacterial species. Evidence of cat-to-human transmission was shown by comparative genomics of isolates from the patient with isolates of her cats.
AB -
Introduction.
Staphylococcus felis is a coagulase-negative staphylococcal species that is commonly isolated from healthy cats. Like other commensal staphylococci,
S. felis can cause opportunistic infections, e.g. otitis externa, skin and urinary tract infections, in cats.
Gap Statement. Several studies have reported within-household transmission between humans and pets and human infections caused by coagulase-positive staphylococci. However, human infections with coagulase-negative staphylococci of zoonotic origin are relatively rare.
Methodology. Culture of a surgical site infection in a 58-year-old woman who underwent a laminectomy revealed dominant growth of
S. felis. The three cats owned by the patient were sampled to investigate potential within-household transmission.
S. felis isolates were sequenced to investigate the relatedness of the isolates and to look for virulence factors and host specific genes.
Results. All cats were colonized with
S. felis. Comparative genomics of the isolates showed that each cat was colonized with a distinct genotype. The patient's isolate clustered with isolates of one of the cats. Sequence analysis of the studied isolates together with 29 publicly available
S. felis genomes detected putative virulence factors that can be crucial in potential interspecies transmission.
Conclusion. The current case is the first reported human infection caused by
S. felis and highlights the zoonotic potential of this bacterial species. Evidence of cat-to-human transmission was shown by comparative genomics of isolates from the patient with isolates of her cats.
KW - Staphylococcus felis
KW - cat
KW - transmission
KW - zoonoses
UR - http://www.scopus.com/inward/record.url?scp=85147893310&partnerID=8YFLogxK
U2 - 10.1099/jmm.0.001661
DO - 10.1099/jmm.0.001661
M3 - Article
C2 - 36763079
SN - 0022-2615
VL - 72
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 2
M1 - 001661
ER -