Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose

Rianne M F van Schie; Talitha I Verhoef; Saskia B Boejharat; Tom Schalekamp; Judith A M Wessels; Saskia le Cessie; Frits R Rosendaal; Felix J M van der Meer; Anthonius de Boer; Anke-Hilse Maitland-van der Zee

doi:10.1515/dmdi-2012-0024

Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose

Rianne M F van Schie, Talitha I Verhoef, Saskia B Boejharat, Tom Schalekamp, Judith A M Wessels, Saskia le Cessie, Frits R Rosendaal, Felix J M van der Meer, Anthonius de Boer, Anke-Hilse Maitland-van der Zee

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.

METHODS: The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.

RESULTS: Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).

CONCLUSIONS: Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.

Original language	English
Pages (from-to)	229-34
Number of pages	6
Journal	Drug Metabolism and Drug Interactions
Volume	27
Issue number	4
DOIs	https://doi.org/10.1515/dmdi-2012-0024
Publication status	Published - 2012

Keywords

Acenocoumarol
Adult
Aged
Aged, 80 and over
Anticoagulants
Drug Interactions
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Male
Middle Aged
Phenprocoumon

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10.1515/dmdi-2012-0024

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van Schie, R. M. F., Verhoef, T. I., Boejharat, S. B., Schalekamp, T., Wessels, J. A. M., le Cessie, S., Rosendaal, F. R., van der Meer, F. J. M., de Boer, A., & Maitland-van der Zee, A.-H. (2012). Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose. Drug Metabolism and Drug Interactions, 27(4), 229-34. https://doi.org/10.1515/dmdi-2012-0024

@article{594e3f2d68a5401d86f8bf541caedefd,

title = "Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose",

abstract = "BACKGROUND: Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.METHODS: The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.RESULTS: Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).CONCLUSIONS: Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.",

keywords = "Acenocoumarol, Adult, Aged, Aged, 80 and over, Anticoagulants, Drug Interactions, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Phenprocoumon",

author = "{van Schie}, {Rianne M F} and Verhoef, {Talitha I} and Boejharat, {Saskia B} and Tom Schalekamp and Wessels, {Judith A M} and {le Cessie}, Saskia and Rosendaal, {Frits R} and {van der Meer}, {Felix J M} and {de Boer}, Anthonius and {Maitland-van der Zee}, Anke-Hilse",

year = "2012",

doi = "10.1515/dmdi-2012-0024",

language = "English",

volume = "27",

pages = "229--34",

journal = "Drug Metabolism and Drug Interactions",

issn = "0792-5077",

publisher = "Walter de Gruyter GmbH",

number = "4",

}

TY - JOUR

T1 - Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose

AU - van Schie, Rianne M F

AU - Verhoef, Talitha I

AU - Boejharat, Saskia B

AU - Schalekamp, Tom

AU - Wessels, Judith A M

AU - le Cessie, Saskia

AU - Rosendaal, Frits R

AU - van der Meer, Felix J M

AU - de Boer, Anthonius

AU - Maitland-van der Zee, Anke-Hilse

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.METHODS: The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.RESULTS: Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).CONCLUSIONS: Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.

AB - BACKGROUND: Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.METHODS: The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.RESULTS: Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).CONCLUSIONS: Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.

KW - Acenocoumarol

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anticoagulants

KW - Drug Interactions

KW - Female

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Male

KW - Middle Aged

KW - Phenprocoumon

U2 - 10.1515/dmdi-2012-0024

DO - 10.1515/dmdi-2012-0024

M3 - Article

C2 - 23096528

SN - 0792-5077

VL - 27

SP - 229

EP - 234

JO - Drug Metabolism and Drug Interactions

JF - Drug Metabolism and Drug Interactions

IS - 4

ER -

Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose

Abstract

Keywords

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