Evaluation of clinico-pathological criteria and the Ki67 index as prognostic indicators in canine insulinoma

F.O. Buishand, M.J.L. Kik, J. Kirpensteijn

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    Abstract

    Vet J. 2010 Jul;185(1):62-7. Epub 2010 May 31. Evaluation of clinico-pathological criteria and the Ki67 index as prognostic indicators in canine insulinoma. Buishand FO, Kik M, Kirpensteijn J. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, 3584 TD Utrecht, The Netherlands. Abstract The establishment of reliable prognostic biomarkers for canine insulinoma are warranted to facilitate optimal patient management. Using univariate and multivariate analyses, the present study evaluated the prognostic power of several clinical and histopathological criteria, as well as the Ki67 index, in 26 dogs with insulinoma. On univariate analysis, stromal fibrosis within these tumours was found to be significantly predictive for survival, while tumour size, the Ki67 index, and TNM (Tumour, Node, Metastasis) stage were significant in the prognosis of both disease-free interval and survival time. On multivariate analysis, tumour size retained predictive power for disease-free intervals, while the Ki67 index proved prognostically significant for both the disease-free interval and overall survival time. This study demonstrates that, in addition to known factors such as tumour size and stage, Ki67 can act as a biomarker of insulinoma that can be used to predict clinical outcome. Copyright 2010 Elsevier Ltd. All rights reserved. PMID: 20570189 [PubMed - indexed for MEDLINE]
    Original languageUndefined/Unknown
    Pages (from-to)62-67
    Number of pages6
    JournalVeterinary Journal
    Volume185
    Issue number1
    Publication statusPublished - 2010

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