Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias

Nicoline M Korthagen; Coline H M van Moorsel; Pieter Zanen; Henk J Ruven; Jan C Grutters

doi:10.1007/s00408-014-9647-9

Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias

Nicoline M Korthagen, Coline H M van Moorsel, Pieter Zanen, Henk J Ruven, Jan C Grutters

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: YKL-40 is a novel biomarker in diseases with inflammation, fibrosis and tissue remodelling. Previously, circulating YKL-40 was shown to be elevated in patients with idiopathic pulmonary fibrosis (IPF) and was associated with survival.

OBJECTIVE: To compare YKL-40 serum levels between IPF and other interstitial pneumonias such as non-specific interstitial pneumonia (NSIP), smoking-related interstitial lung disease (SR-ILD) and cryptogenic organising pneumonia (COP).

MATERIALS AND METHODS: Serum YKL-40 levels were measured in 124 healthy controls and 315 patients. Serial measurements were available in 36 patients with IPF and 6 patients with COP.

RESULTS: Serum YKL-40 levels were elevated in all patient groups compared to controls (p < 0.0001), and highest levels were found in the most fibrotic diseases, which showed worst prognosis.

CONCLUSION: YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis.

Original language	English
Pages (from-to)	975-80
Number of pages	6
Journal	Lung
Volume	192
Issue number	6
DOIs	https://doi.org/10.1007/s00408-014-9647-9
Publication status	Published - Dec 2014
Externally published	Yes

Keywords

Chitinase-like protein
Biomarker
Fibrosis
Diagnosis
Prognosis
IPF

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@article{e6c0dcca1bb64c08b6cdb82c84bf191e,

title = "Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias",

abstract = "INTRODUCTION: YKL-40 is a novel biomarker in diseases with inflammation, fibrosis and tissue remodelling. Previously, circulating YKL-40 was shown to be elevated in patients with idiopathic pulmonary fibrosis (IPF) and was associated with survival.OBJECTIVE: To compare YKL-40 serum levels between IPF and other interstitial pneumonias such as non-specific interstitial pneumonia (NSIP), smoking-related interstitial lung disease (SR-ILD) and cryptogenic organising pneumonia (COP).MATERIALS AND METHODS: Serum YKL-40 levels were measured in 124 healthy controls and 315 patients. Serial measurements were available in 36 patients with IPF and 6 patients with COP.RESULTS: Serum YKL-40 levels were elevated in all patient groups compared to controls (p < 0.0001), and highest levels were found in the most fibrotic diseases, which showed worst prognosis.CONCLUSION: YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis.",

keywords = "Chitinase-like protein, Biomarker, Fibrosis, Diagnosis, Prognosis, IPF",

author = "Korthagen, {Nicoline M} and {van Moorsel}, {Coline H M} and Pieter Zanen and Ruven, {Henk J} and Grutters, {Jan C}",

year = "2014",

month = dec,

doi = "10.1007/s00408-014-9647-9",

language = "English",

volume = "192",

pages = "975--80",

journal = "Lung",

issn = "0341-2040",

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TY - JOUR

T1 - Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias

AU - Korthagen, Nicoline M

AU - van Moorsel, Coline H M

AU - Zanen, Pieter

AU - Ruven, Henk J

AU - Grutters, Jan C

PY - 2014/12

Y1 - 2014/12

N2 - INTRODUCTION: YKL-40 is a novel biomarker in diseases with inflammation, fibrosis and tissue remodelling. Previously, circulating YKL-40 was shown to be elevated in patients with idiopathic pulmonary fibrosis (IPF) and was associated with survival.OBJECTIVE: To compare YKL-40 serum levels between IPF and other interstitial pneumonias such as non-specific interstitial pneumonia (NSIP), smoking-related interstitial lung disease (SR-ILD) and cryptogenic organising pneumonia (COP).MATERIALS AND METHODS: Serum YKL-40 levels were measured in 124 healthy controls and 315 patients. Serial measurements were available in 36 patients with IPF and 6 patients with COP.RESULTS: Serum YKL-40 levels were elevated in all patient groups compared to controls (p < 0.0001), and highest levels were found in the most fibrotic diseases, which showed worst prognosis.CONCLUSION: YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis.

AB - INTRODUCTION: YKL-40 is a novel biomarker in diseases with inflammation, fibrosis and tissue remodelling. Previously, circulating YKL-40 was shown to be elevated in patients with idiopathic pulmonary fibrosis (IPF) and was associated with survival.OBJECTIVE: To compare YKL-40 serum levels between IPF and other interstitial pneumonias such as non-specific interstitial pneumonia (NSIP), smoking-related interstitial lung disease (SR-ILD) and cryptogenic organising pneumonia (COP).MATERIALS AND METHODS: Serum YKL-40 levels were measured in 124 healthy controls and 315 patients. Serial measurements were available in 36 patients with IPF and 6 patients with COP.RESULTS: Serum YKL-40 levels were elevated in all patient groups compared to controls (p < 0.0001), and highest levels were found in the most fibrotic diseases, which showed worst prognosis.CONCLUSION: YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis.

KW - Chitinase-like protein

KW - Biomarker

KW - Fibrosis

KW - Diagnosis

KW - Prognosis

KW - IPF

U2 - 10.1007/s00408-014-9647-9

DO - 10.1007/s00408-014-9647-9

M3 - Article

C2 - 25274153

SN - 0341-2040

VL - 192

SP - 975

EP - 980

JO - Lung

JF - Lung

IS - 6

ER -

Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias

Abstract

Keywords

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