Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

Simona V Antonova; Jeffrey Boeren; H T Marc Timmers; Berend Snel

doi:10.1101/gad.300475.117

Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

Simona V Antonova, Jeffrey Boeren, H T Marc Timmers, Berend Snel

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription. Human TFIID is endowed with chromatin reader and DNA-binding domains and protein interaction surfaces. Fourteen TFIID TATA-binding protein (TBP)-associated factor (TAF) subunits assemble into the holocomplex, which shares subunits with the Spt-Ada-Gcn5-acetyltransferase (SAGA) coactivator. Here, we discuss the structural and functional evolution of TFIID and its divergence from SAGA. Our orthologous tree and domain analyses reveal dynamic gains and losses of epigenetic readers, plant-specific functions of TAF1 and TAF4, the HEAT2-like repeat in TAF2, and, importantly, the pre-LECA origin of TFIID and SAGA. TFIID evolution exemplifies the dynamic plasticity in transcription complexes in the eukaryotic lineage.

Original language	English
Pages (from-to)	888-902
Number of pages	15
Journal	Genes and Development
Volume	33
Issue number	15-16
DOIs	https://doi.org/10.1101/gad.300475.117
Publication status	Published - 1 Aug 2019

Keywords

Biodiversity
Epigenesis, Genetic
Eukaryota/classification
Evolution, Molecular
Gene Expression Regulation
Phylogeny
Transcription Factor TFIID/genetics

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title = "Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID",

abstract = "The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription. Human TFIID is endowed with chromatin reader and DNA-binding domains and protein interaction surfaces. Fourteen TFIID TATA-binding protein (TBP)-associated factor (TAF) subunits assemble into the holocomplex, which shares subunits with the Spt-Ada-Gcn5-acetyltransferase (SAGA) coactivator. Here, we discuss the structural and functional evolution of TFIID and its divergence from SAGA. Our orthologous tree and domain analyses reveal dynamic gains and losses of epigenetic readers, plant-specific functions of TAF1 and TAF4, the HEAT2-like repeat in TAF2, and, importantly, the pre-LECA origin of TFIID and SAGA. TFIID evolution exemplifies the dynamic plasticity in transcription complexes in the eukaryotic lineage.",

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author = "Antonova, {Simona V} and Jeffrey Boeren and Timmers, {H T Marc} and Berend Snel",

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AU - Antonova, Simona V

AU - Boeren, Jeffrey

AU - Timmers, H T Marc

AU - Snel, Berend

PY - 2019/8/1

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AB - The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription. Human TFIID is endowed with chromatin reader and DNA-binding domains and protein interaction surfaces. Fourteen TFIID TATA-binding protein (TBP)-associated factor (TAF) subunits assemble into the holocomplex, which shares subunits with the Spt-Ada-Gcn5-acetyltransferase (SAGA) coactivator. Here, we discuss the structural and functional evolution of TFIID and its divergence from SAGA. Our orthologous tree and domain analyses reveal dynamic gains and losses of epigenetic readers, plant-specific functions of TAF1 and TAF4, the HEAT2-like repeat in TAF2, and, importantly, the pre-LECA origin of TFIID and SAGA. TFIID evolution exemplifies the dynamic plasticity in transcription complexes in the eukaryotic lineage.

KW - Biodiversity

KW - Epigenesis, Genetic

KW - Eukaryota/classification

KW - Evolution, Molecular

KW - Gene Expression Regulation

KW - Phylogeny

KW - Transcription Factor TFIID/genetics

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EP - 902

JO - Genes and Development

JF - Genes and Development

IS - 15-16

ER -

Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

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Keywords

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