Epidermal growth factor induces serine phosphorylation of actin

Sanne van Delft; Arie J. Verkleij; Johannes Boonstra; Paul M.P. van Bergen en Henegouwen

doi:10.1016/0014-5793(94)01359-9

Epidermal growth factor induces serine phosphorylation of actin

Sanne van Delft^*
, Arie J. Verkleij
, Johannes Boonstra
, Paul M.P. van Bergen en Henegouwen

^*Corresponding author for this work

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	FEBS Letters
Volume	357
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(94)01359-9
Publication status	Published - 9 Jan 1995

Keywords

Actin
EGF
EGF-receptor
Phosphorylation

Access to Document

10.1016/0014-5793(94)01359-9

Cite this

@article{5bc282d3e90a4a9c9965a4be6e7c32d0,

title = "Epidermal growth factor induces serine phosphorylation of actin",

abstract = "Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.",

keywords = "Actin, EGF, EGF-receptor, Phosphorylation",

author = "\{van Delft\}, Sanne and Verkleij, \{Arie J.\} and Johannes Boonstra and \{van Bergen en Henegouwen\}, \{Paul M.P.\}",

year = "1995",

month = jan,

day = "9",

doi = "10.1016/0014-5793(94)01359-9",

language = "English",

volume = "357",

pages = "251--254",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Epidermal growth factor induces serine phosphorylation of actin

AU - van Delft, Sanne

AU - Verkleij, Arie J.

AU - Boonstra, Johannes

AU - van Bergen en Henegouwen, Paul M.P.

PY - 1995/1/9

Y1 - 1995/1/9

N2 - Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

AB - Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

KW - Actin

KW - EGF

KW - EGF-receptor

KW - Phosphorylation

UR - https://www.scopus.com/pages/publications/0028816254

U2 - 10.1016/0014-5793(94)01359-9

DO - 10.1016/0014-5793(94)01359-9

M3 - Article

C2 - 7835422

AN - SCOPUS:0028816254

SN - 0014-5793

VL - 357

SP - 251

EP - 254

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Epidermal growth factor induces serine phosphorylation of actin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this