Epidermal growth factor induces serine phosphorylation of actin

Sanne van Delft; Arie J. Verkleij; Johannes Boonstra; Paul M.P. van Bergen en Henegouwen

doi:10.1016/0014-5793(94)01359-9

Epidermal growth factor induces serine phosphorylation of actin

Sanne van Delft^*, Arie J. Verkleij, Johannes Boonstra, Paul M.P. van Bergen en Henegouwen

^*Corresponding author for this work

Sub Cell Biology

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	FEBS Letters
Volume	357
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(94)01359-9
Publication status	Published - 9 Jan 1995

Keywords

Actin
EGF
EGF-receptor
Phosphorylation

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10.1016/0014-5793(94)01359-9

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title = "Epidermal growth factor induces serine phosphorylation of actin",

abstract = "Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.",

keywords = "Actin, EGF, EGF-receptor, Phosphorylation",

author = "{van Delft}, Sanne and Verkleij, {Arie J.} and Johannes Boonstra and {van Bergen en Henegouwen}, {Paul M.P.}",

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AU - van Delft, Sanne

AU - Verkleij, Arie J.

AU - Boonstra, Johannes

AU - van Bergen en Henegouwen, Paul M.P.

PY - 1995/1/9

Y1 - 1995/1/9

N2 - Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

AB - Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

KW - Actin

KW - EGF

KW - EGF-receptor

KW - Phosphorylation

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DO - 10.1016/0014-5793(94)01359-9

M3 - Article

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ER -

Epidermal growth factor induces serine phosphorylation of actin

Abstract

Keywords

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