Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents

Anna Johanna Maria Gemma Boormans; Joyce Dieleman; Marloes Kleinjan; Roy Otten; Maartje Luijten

doi:10.1159/000512891

Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents

Anna Johanna Maria Gemma Boormans, Joyce Dieleman, Marloes Kleinjan, Roy Otten, Maartje Luijten^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: Despite its well-established negative effects, environmental tobacco smoke (ETS) exposure remains highly prevalent worldwide. ETS exposure is associated with a wide range of physical and mental health-related problems among youth, including an increased likelihood to develop nicotine dependence. Up till now, neurocognitive effects of ETS exposure are largely unknown, while such effects could explain the role of ETS exposure in the development of nicotine dependence. Therefore, this preregistered study investigated the role of current ETS exposure in brain functioning associated with smoking cue-reactivity and inhibitory control. Method: Concurrent with functional magnetic resonance imaging, nonsmoking adolescents aged 14-18 years (N = 51) performed a smoking cue-reactivity task, assessing brain functioning to smoking cues, and a Go/NoGo task measuring inhibitory control. ETS exposure was measured using a self-report questionnaire and biochemically verified. Results: No significant associations were observed between current ETS exposure and brain functioning associated with smoking cue-reactivity and inhibitory control. Conclusion: These findings suggest that low-to-moderate levels of current ETS exposure are not associated with increased salience of smoking cues or deficits in inhibitory control in nonsmoking adolescents. Longitudinal research is needed to further clarify the exact effect of lifetime ETS exposure on brain functioning, as well as research focusing on the effects of higher levels of ETS exposure.

Original language	English
Pages (from-to)	341-350
Number of pages	10
Journal	European Addiction Research
Volume	27
Issue number	5
DOIs	https://doi.org/10.1159/000512891
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
This research was funded by a VENI grant (No. 451-15-029) from the Netherlands Organisation for Scientific Research (NWO) to XXXXX. NWO had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This research was part of a larger project funded by a Dutch cancer society grant (No. Ti 2014-6984).

Publisher Copyright:
© 2021 The Author(s) Published by S. Karger AG, Basel.

Funding

This research was funded by a VENI grant (No. 451-15-029) from the Netherlands Organisation for Scientific Research (NWO) to XXXXX. NWO had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This research was part of a larger project funded by a Dutch cancer society grant (No. Ti 2014-6984).

Keywords

Adolescence
Environmental tobacco smoke exposure
Inhibitory control
Neuroimaging
Smoking cue-reactivity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000512891Licence: CC BY-NC

512891Final published version, 464 KBLicence: CC BY-NC

Cite this

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title = "Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents",

abstract = "Introduction: Despite its well-established negative effects, environmental tobacco smoke (ETS) exposure remains highly prevalent worldwide. ETS exposure is associated with a wide range of physical and mental health-related problems among youth, including an increased likelihood to develop nicotine dependence. Up till now, neurocognitive effects of ETS exposure are largely unknown, while such effects could explain the role of ETS exposure in the development of nicotine dependence. Therefore, this preregistered study investigated the role of current ETS exposure in brain functioning associated with smoking cue-reactivity and inhibitory control. Method: Concurrent with functional magnetic resonance imaging, nonsmoking adolescents aged 14-18 years (N = 51) performed a smoking cue-reactivity task, assessing brain functioning to smoking cues, and a Go/NoGo task measuring inhibitory control. ETS exposure was measured using a self-report questionnaire and biochemically verified. Results: No significant associations were observed between current ETS exposure and brain functioning associated with smoking cue-reactivity and inhibitory control. Conclusion: These findings suggest that low-to-moderate levels of current ETS exposure are not associated with increased salience of smoking cues or deficits in inhibitory control in nonsmoking adolescents. Longitudinal research is needed to further clarify the exact effect of lifetime ETS exposure on brain functioning, as well as research focusing on the effects of higher levels of ETS exposure. ",

keywords = "Adolescence, Environmental tobacco smoke exposure, Inhibitory control, Neuroimaging, Smoking cue-reactivity",

author = "Boormans, {Anna Johanna Maria Gemma} and Joyce Dieleman and Marloes Kleinjan and Roy Otten and Maartje Luijten",

note = "Funding Information: This research was funded by a VENI grant (No. 451-15-029) from the Netherlands Organisation for Scientific Research (NWO) to XXXXX. NWO had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This research was part of a larger project funded by a Dutch cancer society grant (No. Ti 2014-6984). Publisher Copyright: {\textcopyright} 2021 The Author(s) Published by S. Karger AG, Basel.",

year = "2021",

month = aug,

doi = "10.1159/000512891",

language = "English",

volume = "27",

pages = "341--350",

journal = "European Addiction Research",

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Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents. / Boormans, Anna Johanna Maria Gemma; Dieleman, Joyce; Kleinjan, Marloes et al.
In: European Addiction Research, Vol. 27, No. 5, 08.2021, p. 341-350.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents

AU - Boormans, Anna Johanna Maria Gemma

AU - Dieleman, Joyce

AU - Kleinjan, Marloes

AU - Otten, Roy

AU - Luijten, Maartje

N1 - Funding Information: This research was funded by a VENI grant (No. 451-15-029) from the Netherlands Organisation for Scientific Research (NWO) to XXXXX. NWO had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This research was part of a larger project funded by a Dutch cancer society grant (No. Ti 2014-6984). Publisher Copyright: © 2021 The Author(s) Published by S. Karger AG, Basel.

PY - 2021/8

Y1 - 2021/8

N2 - Introduction: Despite its well-established negative effects, environmental tobacco smoke (ETS) exposure remains highly prevalent worldwide. ETS exposure is associated with a wide range of physical and mental health-related problems among youth, including an increased likelihood to develop nicotine dependence. Up till now, neurocognitive effects of ETS exposure are largely unknown, while such effects could explain the role of ETS exposure in the development of nicotine dependence. Therefore, this preregistered study investigated the role of current ETS exposure in brain functioning associated with smoking cue-reactivity and inhibitory control. Method: Concurrent with functional magnetic resonance imaging, nonsmoking adolescents aged 14-18 years (N = 51) performed a smoking cue-reactivity task, assessing brain functioning to smoking cues, and a Go/NoGo task measuring inhibitory control. ETS exposure was measured using a self-report questionnaire and biochemically verified. Results: No significant associations were observed between current ETS exposure and brain functioning associated with smoking cue-reactivity and inhibitory control. Conclusion: These findings suggest that low-to-moderate levels of current ETS exposure are not associated with increased salience of smoking cues or deficits in inhibitory control in nonsmoking adolescents. Longitudinal research is needed to further clarify the exact effect of lifetime ETS exposure on brain functioning, as well as research focusing on the effects of higher levels of ETS exposure.

AB - Introduction: Despite its well-established negative effects, environmental tobacco smoke (ETS) exposure remains highly prevalent worldwide. ETS exposure is associated with a wide range of physical and mental health-related problems among youth, including an increased likelihood to develop nicotine dependence. Up till now, neurocognitive effects of ETS exposure are largely unknown, while such effects could explain the role of ETS exposure in the development of nicotine dependence. Therefore, this preregistered study investigated the role of current ETS exposure in brain functioning associated with smoking cue-reactivity and inhibitory control. Method: Concurrent with functional magnetic resonance imaging, nonsmoking adolescents aged 14-18 years (N = 51) performed a smoking cue-reactivity task, assessing brain functioning to smoking cues, and a Go/NoGo task measuring inhibitory control. ETS exposure was measured using a self-report questionnaire and biochemically verified. Results: No significant associations were observed between current ETS exposure and brain functioning associated with smoking cue-reactivity and inhibitory control. Conclusion: These findings suggest that low-to-moderate levels of current ETS exposure are not associated with increased salience of smoking cues or deficits in inhibitory control in nonsmoking adolescents. Longitudinal research is needed to further clarify the exact effect of lifetime ETS exposure on brain functioning, as well as research focusing on the effects of higher levels of ETS exposure.

KW - Adolescence

KW - Environmental tobacco smoke exposure

KW - Inhibitory control

KW - Neuroimaging

KW - Smoking cue-reactivity

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DO - 10.1159/000512891

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AN - SCOPUS:85100740131

SN - 1022-6877

VL - 27

SP - 341

EP - 350

JO - European Addiction Research

JF - European Addiction Research

IS - 5

ER -

Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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