Environmental Tobacco Smoke Exposure and Brain Functioning Associated with Smoking Cue-Reactivity and Inhibitory Control in Nonsmoking Adolescents

Anna Johanna Maria Gemma Boormans, Joyce Dieleman, Marloes Kleinjan, Roy Otten, Maartje Luijten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: Despite its well-established negative effects, environmental tobacco smoke (ETS) exposure remains highly prevalent worldwide. ETS exposure is associated with a wide range of physical and mental health-related problems among youth, including an increased likelihood to develop nicotine dependence. Up till now, neurocognitive effects of ETS exposure are largely unknown, while such effects could explain the role of ETS exposure in the development of nicotine dependence. Therefore, this preregistered study investigated the role of current ETS exposure in brain functioning associated with smoking cue-reactivity and inhibitory control. Method: Concurrent with functional magnetic resonance imaging, nonsmoking adolescents aged 14-18 years (N = 51) performed a smoking cue-reactivity task, assessing brain functioning to smoking cues, and a Go/NoGo task measuring inhibitory control. ETS exposure was measured using a self-report questionnaire and biochemically verified. Results: No significant associations were observed between current ETS exposure and brain functioning associated with smoking cue-reactivity and inhibitory control. Conclusion: These findings suggest that low-to-moderate levels of current ETS exposure are not associated with increased salience of smoking cues or deficits in inhibitory control in nonsmoking adolescents. Longitudinal research is needed to further clarify the exact effect of lifetime ETS exposure on brain functioning, as well as research focusing on the effects of higher levels of ETS exposure.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalEuropean Addiction Research
Volume27
Issue number5
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Adolescence
  • Environmental tobacco smoke exposure
  • Inhibitory control
  • Neuroimaging
  • Smoking cue-reactivity

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