Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator

Hiroyuki Asanuma; Hiroyuki Hayashi; Jing Zhao; Xingguo Liang; Akira Yamazawa; Takeshi Kuramochi; Daijiro Matsunaga; Yuichiro Aiba; Hiromu Kashida; Makoto Komiyama

doi:10.1039/b611078a

Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator

Hiroyuki Asanuma^*, Hiroyuki Hayashi, Jing Zhao, Xingguo Liang, Akira Yamazawa, Takeshi Kuramochi, Daijiro Matsunaga, Yuichiro Aiba, Hiromu Kashida, Makoto Komiyama

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

By introducing an intercalator through d-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

Original language	English
Pages (from-to)	5062-5064
Number of pages	3
Journal	Chemical Communications
Issue number	48
DOIs	https://doi.org/10.1039/b611078a
Publication status	Published - 2006
Externally published	Yes

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10.1039/b611078a

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@article{ba4247ffc0da4754acc300ce9edbe6cd,

title = "Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator",

abstract = "By introducing an intercalator through d-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.",

author = "Hiroyuki Asanuma and Hiroyuki Hayashi and Jing Zhao and Xingguo Liang and Akira Yamazawa and Takeshi Kuramochi and Daijiro Matsunaga and Yuichiro Aiba and Hiromu Kashida and Makoto Komiyama",

year = "2006",

doi = "10.1039/b611078a",

language = "English",

pages = "5062--5064",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "48",

}

TY - JOUR

T1 - Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator

AU - Asanuma, Hiroyuki

AU - Hayashi, Hiroyuki

AU - Zhao, Jing

AU - Liang, Xingguo

AU - Yamazawa, Akira

AU - Kuramochi, Takeshi

AU - Matsunaga, Daijiro

AU - Aiba, Yuichiro

AU - Kashida, Hiromu

AU - Komiyama, Makoto

PY - 2006

Y1 - 2006

N2 - By introducing an intercalator through d-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

AB - By introducing an intercalator through d-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

UR - http://www.scopus.com/inward/record.url?scp=33845249999&partnerID=8YFLogxK

U2 - 10.1039/b611078a

DO - 10.1039/b611078a

M3 - Article

C2 - 17146528

AN - SCOPUS:33845249999

SN - 1359-7345

SP - 5062

EP - 5064

JO - Chemical Communications

JF - Chemical Communications

IS - 48

ER -

Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator

Abstract

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