Engineering of primary carbon metabolism in filamentous fungi

Tania Chroumpi, Miia R. Mäkelä, Ronald P. de Vries

Research output: Contribution to journalReview articlepeer-review

Abstract

Filamentous fungi are important industrial cell factories used for the production of a wide range of enzymes and metabolites. Their primary metabolism is a significant source of industrially important compounds, as well as of monomeric building blocks for the production of secondary metabolites and extracellular enzymes. Therefore, large efforts have been made towards the development of suitable strains for the industrial scale production of primary metabolites. Over the last decades, metabolic engineering of primary metabolism has become a powerful tool to enhance production of both primary and secondary metabolites. This review summarises the different metabolic engineering methods that have been applied to rationally improve the production of industrially relevant primary metabolites in filamentous fungi, and discusses related challenges and future perspectives.

Original languageEnglish
Article number107551
Number of pages23
JournalBiotechnology Advances
Volume43
DOIs
Publication statusPublished - 1 Nov 2020

Funding

TC was supported by a grant of the of NWO ALWOP.233 to RPdV. The Academy of Finland grant no. 308284 to MRM is acknowledged.

Keywords

  • D-galacturonic acid pathway
  • Filamentous fungi
  • genome-scale models
  • glycolysis
  • metabolic engineering
  • organic acids
  • Pentose catabolic pathway
  • primary metabolism
  • TCA cycle

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