Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Dan T.M. Nguyen, Max Koppers*, Ginny G. Farías*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.

Original languageEnglish
Article number102357
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume88
DOIs
Publication statusPublished - Jun 2024

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