Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Dan T.M. Nguyen; Max Koppers; Ginny G. Farías

doi:10.1016/j.ceb.2024.102357

Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Dan T.M. Nguyen, Max Koppers^*, Ginny G. Farías^*

^*Corresponding author for this work

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Review article › peer-review

Abstract

In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.

Original language	English
Article number	102357
Number of pages	9
Journal	Current Opinion in Cell Biology
Volume	88
DOIs	https://doi.org/10.1016/j.ceb.2024.102357
Publication status	Published - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Funding

This review was supported by funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement (ITN-SAND860035) to G.G.F, the European Research Council (ERC-StG 950617) to G.G.F, and the Netherlands Organization for Scientific Research (NWO) through a VIDI grant (016.VIDI.189.019) to G.G.F., and a VENI grant (VI.Veni.202.113) to M.K.

Funders	Funder number
Horizon 2020
H2020 Marie Skłodowska-Curie Actions	ITN-SAND860035
European Research Council	ERC-StG 950617
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	VI.Veni.202.113

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1-s2.0-S095506742400036X-mainFinal published version, 1.37 MBLicence: CC BY

Cite this

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abstract = "In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.",

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AU - Farías, Ginny G.

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AB - In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.

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DO - 10.1016/j.ceb.2024.102357

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AN - SCOPUS:85190262561

SN - 0955-0674

VL - 88

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

M1 - 102357

ER -

Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Abstract

Bibliographical note

Funding

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