Elemental composition of particulate matter and the association with lung function

Marloes Eeftens; Gerard Hoek; Olena Gruzieva; Anna Mölter; Raymond Agius; Rob Beelen; Bert Brunekreef; Adnan Custovic; Josef Cyrys; Elaine Fuertes; Joachim Heinrich; Barbara Hoffmann; Kees de Hoogh; Aleksandra Jedynska; Menno Keuken; Claudia Klümper; Ingeborg Kooter; Ursula Krämer; Michal Korek; Gerard H Koppelman; Thomas A J Kuhlbusch; Angela Simpson; Henriëtte A Smit; Ming-Yi Tsai; Meng Wang; Kathrin Wolf; Göran Pershagen; Ulrike Gehring

doi:10.1097/EDE.0000000000000136

Elemental composition of particulate matter and the association with lung function

Marloes Eeftens, Gerard Hoek, Olena Gruzieva, Anna Mölter, Raymond Agius, Rob Beelen, Bert Brunekreef, Adnan Custovic, Josef Cyrys, Elaine Fuertes, Joachim Heinrich, Barbara Hoffmann, Kees de Hoogh, Aleksandra Jedynska, Menno Keuken, Claudia Klümper, Ingeborg Kooter, Ursula Krämer, Michal Korek, Gerard H KoppelmanThomas A J Kuhlbusch, Angela Simpson, Henriëtte A Smit, Ming-Yi Tsai, Meng Wang, Kathrin Wolf, Göran Pershagen, Ulrike Gehring

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies.

METHODS: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA (The Netherlands)-for which lung function measurements were available for study subjects at the age of 6 or 8 years. Individual annual average residential exposure to copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 μm (PM2.5) and smaller than 10 μm (PM10) was estimated using land-use regression models. Associations between air pollution and lung function were analyzed by linear regression within cohorts, adjusting for potential confounders, and then combined by random effects meta-analysis.

RESULTS: We observed small reductions in forced expiratory volume in the first second, forced vital capacity, and peak expiratory flow related to exposure to most elemental pollutants, with the most substantial negative associations found for nickel and sulfur. PM10 nickel and PM10 sulfur were associated with decreases in forced expiratory volume in the first second of 1.6% (95% confidence interval = 0.4% to 2.7%) and 2.3% (-0.1% to 4.6%) per increase in exposure of 2 and 200 ng/m, respectively. Associations remained after adjusting for PM mass. However, associations with these elements were not evident in all cohorts, and heterogeneity of associations with exposure to various components was larger than for exposure to PM mass.

CONCLUSIONS: Although we detected small adverse effects on lung function associated with annual average levels of some of the evaluated elements (particularly nickel and sulfur), lower lung function was more consistently associated with increased PM mass.

Original language	English
Pages (from-to)	648-57
Number of pages	10
Journal	Epidemiology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1097/EDE.0000000000000136
Publication status	Published - Sept 2014

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Eeftens, M., Hoek, G., Gruzieva, O., Mölter, A., Agius, R., Beelen, R., Brunekreef, B., Custovic, A., Cyrys, J., Fuertes, E., Heinrich, J., Hoffmann, B., de Hoogh, K., Jedynska, A., Keuken, M., Klümper, C., Kooter, I., Krämer, U., Korek, M., ... Gehring, U. (2014). Elemental composition of particulate matter and the association with lung function. Epidemiology, 25(5), 648-57. https://doi.org/10.1097/EDE.0000000000000136

@article{c94fa029762b4d9bae019c8ddbaad599,

title = "Elemental composition of particulate matter and the association with lung function",

abstract = "BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies.METHODS: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA (The Netherlands)-for which lung function measurements were available for study subjects at the age of 6 or 8 years. Individual annual average residential exposure to copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 μm (PM2.5) and smaller than 10 μm (PM10) was estimated using land-use regression models. Associations between air pollution and lung function were analyzed by linear regression within cohorts, adjusting for potential confounders, and then combined by random effects meta-analysis.RESULTS: We observed small reductions in forced expiratory volume in the first second, forced vital capacity, and peak expiratory flow related to exposure to most elemental pollutants, with the most substantial negative associations found for nickel and sulfur. PM10 nickel and PM10 sulfur were associated with decreases in forced expiratory volume in the first second of 1.6% (95% confidence interval = 0.4% to 2.7%) and 2.3% (-0.1% to 4.6%) per increase in exposure of 2 and 200 ng/m, respectively. Associations remained after adjusting for PM mass. However, associations with these elements were not evident in all cohorts, and heterogeneity of associations with exposure to various components was larger than for exposure to PM mass.CONCLUSIONS: Although we detected small adverse effects on lung function associated with annual average levels of some of the evaluated elements (particularly nickel and sulfur), lower lung function was more consistently associated with increased PM mass.",

author = "Marloes Eeftens and Gerard Hoek and Olena Gruzieva and Anna M{\"o}lter and Raymond Agius and Rob Beelen and Bert Brunekreef and Adnan Custovic and Josef Cyrys and Elaine Fuertes and Joachim Heinrich and Barbara Hoffmann and {de Hoogh}, Kees and Aleksandra Jedynska and Menno Keuken and Claudia Kl{\"u}mper and Ingeborg Kooter and Ursula Kr{\"a}mer and Michal Korek and Koppelman, {Gerard H} and Kuhlbusch, {Thomas A J} and Angela Simpson and Smit, {Henri{\"e}tte A} and Ming-Yi Tsai and Meng Wang and Kathrin Wolf and G{\"o}ran Pershagen and Ulrike Gehring",

year = "2014",

month = sep,

doi = "10.1097/EDE.0000000000000136",

language = "English",

volume = "25",

pages = "648--57",

journal = "Epidemiology",

issn = "1044-3983",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "5",

}

Eeftens, M, Hoek, G, Gruzieva, O, Mölter, A, Agius, R, Beelen, R, Brunekreef, B, Custovic, A, Cyrys, J, Fuertes, E, Heinrich, J, Hoffmann, B, de Hoogh, K, Jedynska, A, Keuken, M, Klümper, C, Kooter, I, Krämer, U, Korek, M, Koppelman, GH, Kuhlbusch, TAJ, Simpson, A, Smit, HA, Tsai, M-Y, Wang, M, Wolf, K, Pershagen, G & Gehring, U 2014, 'Elemental composition of particulate matter and the association with lung function', Epidemiology, vol. 25, no. 5, pp. 648-57. https://doi.org/10.1097/EDE.0000000000000136

TY - JOUR

T1 - Elemental composition of particulate matter and the association with lung function

AU - Eeftens, Marloes

AU - Hoek, Gerard

AU - Gruzieva, Olena

AU - Mölter, Anna

AU - Agius, Raymond

AU - Beelen, Rob

AU - Brunekreef, Bert

AU - Custovic, Adnan

AU - Cyrys, Josef

AU - Fuertes, Elaine

AU - Heinrich, Joachim

AU - Hoffmann, Barbara

AU - de Hoogh, Kees

AU - Jedynska, Aleksandra

AU - Keuken, Menno

AU - Klümper, Claudia

AU - Kooter, Ingeborg

AU - Krämer, Ursula

AU - Korek, Michal

AU - Koppelman, Gerard H

AU - Kuhlbusch, Thomas A J

AU - Simpson, Angela

AU - Smit, Henriëtte A

AU - Tsai, Ming-Yi

AU - Wang, Meng

AU - Wolf, Kathrin

AU - Pershagen, Göran

AU - Gehring, Ulrike

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies.METHODS: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA (The Netherlands)-for which lung function measurements were available for study subjects at the age of 6 or 8 years. Individual annual average residential exposure to copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 μm (PM2.5) and smaller than 10 μm (PM10) was estimated using land-use regression models. Associations between air pollution and lung function were analyzed by linear regression within cohorts, adjusting for potential confounders, and then combined by random effects meta-analysis.RESULTS: We observed small reductions in forced expiratory volume in the first second, forced vital capacity, and peak expiratory flow related to exposure to most elemental pollutants, with the most substantial negative associations found for nickel and sulfur. PM10 nickel and PM10 sulfur were associated with decreases in forced expiratory volume in the first second of 1.6% (95% confidence interval = 0.4% to 2.7%) and 2.3% (-0.1% to 4.6%) per increase in exposure of 2 and 200 ng/m, respectively. Associations remained after adjusting for PM mass. However, associations with these elements were not evident in all cohorts, and heterogeneity of associations with exposure to various components was larger than for exposure to PM mass.CONCLUSIONS: Although we detected small adverse effects on lung function associated with annual average levels of some of the evaluated elements (particularly nickel and sulfur), lower lung function was more consistently associated with increased PM mass.

AB - BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies.METHODS: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA (The Netherlands)-for which lung function measurements were available for study subjects at the age of 6 or 8 years. Individual annual average residential exposure to copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 μm (PM2.5) and smaller than 10 μm (PM10) was estimated using land-use regression models. Associations between air pollution and lung function were analyzed by linear regression within cohorts, adjusting for potential confounders, and then combined by random effects meta-analysis.RESULTS: We observed small reductions in forced expiratory volume in the first second, forced vital capacity, and peak expiratory flow related to exposure to most elemental pollutants, with the most substantial negative associations found for nickel and sulfur. PM10 nickel and PM10 sulfur were associated with decreases in forced expiratory volume in the first second of 1.6% (95% confidence interval = 0.4% to 2.7%) and 2.3% (-0.1% to 4.6%) per increase in exposure of 2 and 200 ng/m, respectively. Associations remained after adjusting for PM mass. However, associations with these elements were not evident in all cohorts, and heterogeneity of associations with exposure to various components was larger than for exposure to PM mass.CONCLUSIONS: Although we detected small adverse effects on lung function associated with annual average levels of some of the evaluated elements (particularly nickel and sulfur), lower lung function was more consistently associated with increased PM mass.

U2 - 10.1097/EDE.0000000000000136

DO - 10.1097/EDE.0000000000000136

M3 - Article

C2 - 25061921

SN - 1044-3983

VL - 25

SP - 648

EP - 657

JO - Epidemiology

JF - Epidemiology

IS - 5

ER -

Elemental composition of particulate matter and the association with lung function

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