Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation

Viktor Szatmári, Yuan Ji, Bianca van Herwijnen, Mei Feng, Michael Zhou Wang, Alexandre Bossu, Marcel A G van der Heyden

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    BACKGROUND: The inward rectifier inhibitor pentamidine analogue 6 (PA-6) is effective in cardioversion of goats with persistent rapid pacing induced atrial fibrillation (AF) and is not proarrhythmic in dogs with experimental chronic 3rd-degree AV block. Efficacy and safety in the clinical setting are unknown.

    HYPOTHESIS: That PA-6 would be effective in converting AF to sinus rhythm (SR) in dogs with naturally occurring AF, without the presence of overt adverse effects.

    ANIMALS: Ten client-owned large and giant breed dogs.

    METHODS: Animals with persistent or permanent AF were recruited for our prospective study. PA-6 was administered IV as a bolus of 2.5 mg/kg 10 min-1 followed by a maintenance infusion of 0.04 mg/kg min-1 for a maximum of 50 minutes in conscious dogs. Standard 6 lead limb ECG was recorded during the infusion. Visible and audible signs of adverse effects were scored during the entire procedure.

    RESULTS: PA-6 did not induce changes in QRS duration (54.7 ± 4.6 versus 56.7 ± 6.1 ms, P = .42), QTc interval (241.1 ± 19.5 versus 258.7 ± 19.8 ms, P = .061) or RR interval (363.4 ± 84.6 versus 440.8 ± 96.3 ms, P = .072) at the end of the bolus. No cardioversion to SR was observed in any dog. Three dogs displayed no adverse effects. Five dogs had premature ventricular depolarizations during PA-6 infusion on the ECG. Respiratory distress with laryngeal stridor, subtle muscle twitching, and mild generalized muscular weakness were noncardiac adverse effects observed in 5 dogs. Adverse effects resolved spontaneously.

    CONCLUSIONS AND CLINICAL IMPORTANCE: Chronic naturally occurring AF in large and giant breed dogs could not be cardioverted to SR by PA-6.

    Original languageEnglish
    Pages (from-to)1549-1554
    JournalJournal of Veterinary Internal Medicine
    Volume32
    Issue number5
    Early online date5 Aug 2018
    DOIs
    Publication statusPublished - Sept 2019

    Keywords

    • adverse effects
    • arrhythmia
    • inward rectifier current
    • plasma
    • respiratory distress
    • stridor

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