Effects of short-chain galacto- and long-chain fructo-oligosaccharides on systemic and local immune status during pregnancy

N van Vlies, A Hogenkamp, S Thijssen, G M Dingjan, K Knipping, J Garssen, L M J Knippels

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Nondigestible oligosaccharides can positively influence health via various mechanisms. During pregnancy, supplementation of nondigestible oligosaccharides has positive effects on hypertension and metabolism and may be used to ameliorate pregnancy-related metabolic disturbances. In the nonpregnant state, nondigestible oligosaccharides have been shown to induce a tolerogenic immune response mediated by T-regulatory cells. Since relatively little is known about the effects of nondigestible oligosaccharides on the immune system during pregnancy, pregnant mice were supplemented with a specific mixture of short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS; ratio 9:1). Systemic and local immune parameters were analyzed on day 18 of pregnancy. This study shows that, compared with virgin mice, scGOS/lcFOS supplementation appears to elicit a more tolerogenic immune reaction in pregnant mice and supplementation does not increase the Th1-dependent delayed type hypersensitivity response in pregnant mice as it does in virgin mice.

Original languageEnglish
Pages (from-to)161-8
Number of pages8
JournalJournal of Reproductive Immunology
Volume94
Issue number2
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Cytokines
  • Dietary Supplements
  • Female
  • Fructose
  • Galactose
  • Hypersensitivity, Delayed
  • Immune Tolerance
  • Influenza Vaccines
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Oligosaccharides
  • Pregnancy
  • Th1 Cells
  • Th1-Th2 Balance

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