Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review

Guangcan Chen; Tengyang Huang; Yifeng Dai; Xia Huo; Xijin Xu

doi:10.1016/j.ecoenv.2025.117705

Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review

Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

Research output: Contribution to journal › Review article › peer-review

Abstract

Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.

Original language	English
Article number	117705
Journal	Ecotoxicology and Environmental Safety
Volume	289
DOIs	https://doi.org/10.1016/j.ecoenv.2025.117705
Publication status	Published - Jan 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 The Authors

Funding

This work was supported by the National Natural Science Foundation of China (22376079) , Guangdong Natural Science Foundation (2024A1515013294) .

Funders	Funder number
National Natural Science Foundation of China	22376079
Guangdong Natural Science Foundation	2024A1515013294

Keywords

Epigenetic modification
Inflammatory responses
Intestinal microbiome
NAD -dependent deacetylase
Pollutant exposure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ecoenv.2025.117705Licence: CC BY-NC-ND

Cite this

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title = "Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review",

abstract = "Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.",

keywords = "Epigenetic modification, Inflammatory responses, Intestinal microbiome, NAD -dependent deacetylase, Pollutant exposure",

author = "Guangcan Chen and Tengyang Huang and Yifeng Dai and Xia Huo and Xijin Xu",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = jan,

doi = "10.1016/j.ecoenv.2025.117705",

language = "English",

volume = "289",

journal = "Ecotoxicology and Environmental Safety",

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T1 - Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review

AU - Chen, Guangcan

AU - Huang, Tengyang

AU - Dai, Yifeng

AU - Huo, Xia

AU - Xu, Xijin

PY - 2025/1

Y1 - 2025/1

N2 - Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.

AB - Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.

KW - Epigenetic modification

KW - Inflammatory responses

KW - Intestinal microbiome

KW - NAD -dependent deacetylase

KW - Pollutant exposure

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U2 - 10.1016/j.ecoenv.2025.117705

DO - 10.1016/j.ecoenv.2025.117705

M3 - Review article

SN - 0147-6513

VL - 289

JO - Ecotoxicology and Environmental Safety

JF - Ecotoxicology and Environmental Safety

M1 - 117705

ER -

Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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