Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Jonna K van Vulpen; Martina E Schmidt; Miranda J Velthuis; Joachim Wiskemann; Andreas Schneeweiss; Roel C H Vermeulen; Nina Habermann; Cornelia M Ulrich; Petra H M Peeters; Elsken van der Wall; Anne M May; Karen Steindorf

doi:10.1007/s10549-017-4608-7

Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Jonna K van Vulpen, Martina E Schmidt, Miranda J Velthuis, Joachim Wiskemann, Andreas Schneeweiss, Roel C H Vermeulen, Nina Habermann, Cornelia M Ulrich, Petra H M Peeters, Elsken van der Wall, Anne M May, Karen Steindorf

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. [email protected].
Netherlands Comprehensive Cancer Organisation (IKNL), P.O. Box 19079, 3501 DB, Utrecht, The Netherlands.
Division of Medical Oncology, University Clinic Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
School of Public Health, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
University Medical Center Utrecht
Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.

METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6-9 months post-baseline.

RESULTS: Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21).

CONCLUSIONS: Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.

Original language	English
Pages (from-to)	421-431
Number of pages	11
Journal	Breast Cancer Research and Treatment
Volume	168
Issue number	2
DOIs	https://doi.org/10.1007/s10549-017-4608-7
Publication status	Published - Apr 2018

Keywords

Exercise
Breast cancer
Fatigue
Chemotherapy
Infammation
Mechanisms

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van Vulpen, J. K., Schmidt, M. E., Velthuis, M. J., Wiskemann, J., Schneeweiss, A., Vermeulen, R. C. H., Habermann, N., Ulrich, C. M., Peeters, P. H. M., van der Wall, E., May, A. M., & Steindorf, K. (2018). Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy. Breast Cancer Research and Treatment, 168(2), 421-431. https://doi.org/10.1007/s10549-017-4608-7

@article{fea0b479a252418d95848126f5d880ad,

title = "Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy",

abstract = "PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6-9 months post-baseline.RESULTS: Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21).CONCLUSIONS: Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.",

keywords = "Exercise, Breast cancer, Fatigue, Chemotherapy, Infammation, Mechanisms",

author = "{van Vulpen}, {Jonna K} and Schmidt, {Martina E} and Velthuis, {Miranda J} and Joachim Wiskemann and Andreas Schneeweiss and Vermeulen, {Roel C H} and Nina Habermann and Ulrich, {Cornelia M} and Peeters, {Petra H M} and {van der Wall}, Elsken and May, {Anne M} and Karen Steindorf",

year = "2018",

month = apr,

doi = "10.1007/s10549-017-4608-7",

language = "English",

volume = "168",

pages = "421--431",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

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number = "2",

}

van Vulpen, JK, Schmidt, ME, Velthuis, MJ, Wiskemann, J, Schneeweiss, A, Vermeulen, RCH, Habermann, N, Ulrich, CM, Peeters, PHM, van der Wall, E, May, AM & Steindorf, K 2018, 'Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy', Breast Cancer Research and Treatment, vol. 168, no. 2, pp. 421-431. https://doi.org/10.1007/s10549-017-4608-7

TY - JOUR

T1 - Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

AU - van Vulpen, Jonna K

AU - Schmidt, Martina E

AU - Velthuis, Miranda J

AU - Wiskemann, Joachim

AU - Schneeweiss, Andreas

AU - Vermeulen, Roel C H

AU - Habermann, Nina

AU - Ulrich, Cornelia M

AU - Peeters, Petra H M

AU - van der Wall, Elsken

AU - May, Anne M

AU - Steindorf, Karen

PY - 2018/4

Y1 - 2018/4

N2 - PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6-9 months post-baseline.RESULTS: Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21).CONCLUSIONS: Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.

AB - PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6-9 months post-baseline.RESULTS: Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21).CONCLUSIONS: Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.

KW - Exercise

KW - Breast cancer

KW - Fatigue

KW - Chemotherapy

KW - Infammation

KW - Mechanisms

U2 - 10.1007/s10549-017-4608-7

DO - 10.1007/s10549-017-4608-7

M3 - Article

C2 - 29235043

SN - 0167-6806

VL - 168

SP - 421

EP - 431

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 2

ER -

Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

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